In a nutshell This study examined the effect of physical activity on the development and progression of kidney disease in type 1 diabetes (T1D). Some background Long-term hyperglycemia (high blood glucose levels) can result in many complications for diabetics. Diabetic nephropathy is a progressive kidney disease whereby...
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In a nutshell This study aimed to determine the effectiveness of a closed-loop delivery system in type 1 diabetes patients living at home. Some background An insulin pump allows the patient to enter the carbohydrate content of a meal, releasing an appropriate amount of insulin based on this estimation. A continuous glucose monitor is a...
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In a nutshell This trial investigated whether an artificial pancreas could automatically adjust the insulin dose when an initial insulin dose was administered based on an individual's weight. Some background A bihormonal bionic pancreas is an artificial pancreas. This system consists of a continuous glucose monitor (CGM) and an...
Read MoreIn a nutshell This study examined whether diazoxide (Proglycem) can improve awareness of low blood glucose (sugar) in type 1 diabetic patients. Some background Patients with type 1 diabetes do not produce the hormone insulin, which is needed to break down the glucose taken in from food. The main treatment for type 1 diabetics is insulin...
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In a nutshell This study compared the addition of the new drug liraglutide (Victoza) to the addition of short-acting insulin in type 2 diabetics already treated with long-acting insulin and metformin. Some background Type 2 diabetes is a progressive disease. In the beginning patients may be able to control their blood glucose (sugar) with...
Read MoreIn a nutshell This study examined the use of smartphone technology to automate the glucose monitoring and insulin delivery systems of an artificial pancreas. Some background The artificial pancreas, which delivers insulin through an insulin pump implanted in the abdomen based on continuous monitoring of blood glucose (sugar) levels, is an...
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In a nutshell This study examined the factors involved in the successful control of hypoglycemia with an insulin-glucagon pump. Some background Hypoglycemia (dangerously low blood glucose [sugar] levels) is a common side effect of insulin therapy for type 1 diabetes mellitus. Hypoglycemia can occur when there is too much insulin at any one time....
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In a nutshell This study examined the use of the sulphonylurea glimepiride (Amaryl) in patients with long-standing (10 or more years) type 2 diabetes mellitus. Some background Patients with type 2 diabetes mellitus either do not produce enough or are not sensitive to insulin, the hormone which helps the body break down the glucose (sugar) that is...
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In a nutshell The authors evaluated the prevalence of insulin-related hypoglycemia requiring emergency department visits, and the associated risk factors. Some background Insulin is a cornerstone of type 1 diabetes treatment and is increasingly introduced early in the treatment course for patients with type 2 diabetes. However, it remains one...
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In a nutshell The authors aimed to evaluate the pain associated with subcutaneous injection into the thigh and abdomen of different combinations of injection speeds and volumes. Some background Subcutaneous (applied under the skin) injection of insulin for diabetes control can be associated with pain and discomfort, leading to inadequate treatment...
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In a nutshell This study examined the effect of islet transplantation on hypoglycemia in type 1 diabetes patients. Some background A normal pancreas produces both insulin and glucagon. These hormones perform opposite functions: insulin decreases blood glucose levels while glucagon...
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In a nutshell This study evaluated the influence of systemic insulin delivery on liver glycogen levels in patients with type 1 diabetes mellitus. Some background Type I diabetes is an autoimmune disease where the body no longer produces insulin. In the liver, insulin promotes glucose uptake by stimulating its storage as glycogen while...
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