In a nutshell This phase 1 trial will investigate the safety of an experimental drug, XmAb22841 (XmAb), to treat advanced cancer. The main outcome will be the safety and tolerability of XmAb. This study is recruiting in Georgia and Texas, USA. The details Advanced cancer can be difficult to treat. New drugs are being developed to...
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In a nutshell This study wanted to find out if advances in the treatment of melanoma over the last 60 years have had an impact on the survival of patients. The study found that while modern drug therapy improves survival, the most effective approach is to surgically remove the tumors that have spread through the body. Some background Melanoma can be...
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In a nutshell This study wanted to find out what the best timing is for treating patients with stage 3 melanoma with ipilimumab (Yervoy) and nivolumab (Opdivo). The study found that the best timing was two cycles of ipilimumab 1 mg/kg plus nivolumab 3 mg/kg every three weeks. Some background Ipilimumab and nivolumab are medications used to treat...
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In a nutshell This study evaluated the safety and effectiveness of dabrafenib (Tafinlar) and trametinib (Mekinist) together before surgery to remove stage three melanoma. The study found that a high proportion of patients treated in this way had no signs of cancer left. Some background Dabrafenib and trametinib are...
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Nanodrugs have been around for some time. In fact, over 250 drugs using nanotechnology that have been approved by the FDA and are in clinical use. The name nanodrug or nanopharmaceuticals refers to the size of the particle that is created to house the medication. A nano is very tiny: nanoparticles are between 1 and 100 nanometers in at least one of its...
Read MoreIn a nutshell This phase 1 study will investigate the dose range and effectiveness of an experimental drug, XmAb23104, in the treatment of advanced melanoma and other solid tumors. The main outcome will be the safety and tolerability of XmAb23104. This trial is recruiting in Georgia, Texas, and Virginia, the United States. The details...
Read MoreIn a nutshell This study wanted to find out how well patients with advanced melanoma with mutations (abnormal genes) survive when treated with dabrafenib (Tafinlar) and trametinib (Mekinist) combination. The study found that long term, patients survived moderately well with this treatment. Some background Advanced melanoma can be hard to treat. In...
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In a nutshell This study examined the long-term outcomes of patients with melanoma who received surgery and high-dose interferon-α (HDI). This study found that HDI treatment resulted in a decreased chance of the cancer coming back after 17 years. Some background Surgery followed by anti-cancer therapy has remained the standard of care...
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In a nutshell This study evaluated the quality of life for survivors of melanoma who received immunotherapy. This study found that melanoma survivors had a significantly lower quality of life compared to the general population. Some background Immune checkpoint inhibitors are a new class of anti-cancer drugs that take advantage of the...
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In a nutshell This article investigated the need for restaging in patients with stage IIIB and IIIC melanoma before starting adjuvant therapy (AT; treatment after surgery). The authors concluded that restaging should be considered for these high-risk patients before starting the AT. Some background Melanoma a type of skin cancer...
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In a nutshell This article investigated the safety and effectiveness of nivolumab (Opdivo) in combination with stereotactic body radiotherapy (SBRT) for patients with locally advanced melanoma unsuitable for surgery. The authors concluded that this therapy is effective with manageable side effects in these...
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In a nutshell This study reviewed the 2019 guidelines on the treatment of melanoma. Some background Cutaneous (skin) melanoma (CM) is a common form of cancer. It can be aggressive if found late. New treatments are constantly being developed. It is important to review these options to improve patient care. Systemic therapy (ST) is one treatment...
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