In a nutshell This study aimed to evaluate the effect of stem cell source on haploidentical transplantation with post-transplantation cyclophosphamide (a chemotherapy) in patients with acute leukemia. This study concluded that the use of peripheral blood stem cells increases the risk of side effects for these patients. Some background Patients...
Read MoreIn a nutshell This study aimed to compare myeloablative transplant and a sequential approach treatment in patients with relapsed or refractory acute myeloid leukemia. This study concluded that both treatments had similar outcomes for these patients. Some background Allogeneic hematopoietic stem cell transplantation (HSCT) is the only...
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In a nutshell This study reviewed evidence on the dose management of dasatinib (Sprycel) for chronic myeloid leukemia (CML). Some background Tyrosine kinase inhibitor (TKI) therapy is a standard first-line treatment for CML. Many patients achieve optimal response to TKI therapy and have a near-normal life expectancy. However, this response is lost...
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In a nutshell This phase 3 trial aims to determine the effectiveness of Iomab-B before an hematopoietic stem cell transplantation compared to conventional treatment. The outcome to be measured is remission (no disease) and survival. The details Acute myeloid leukemia is a type of bone marrow cancer. Iomab-B is a drug in development for...
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In a nutshell This trial aims to see the effect of a blood thinning drug apixaban (Eliquis) in preventing blood clots in children with leukemia or lymphoma who are receiving chemotherapy. The main outcome to be measured is the occurrence of any clotting problems or bleeding side effects. The details Patients with cancer are more at risk...
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In a nutshell This phase 1 and 2 trial aims to determine the effectiveness and optimal dose of Axitinib and Bosutinib in patients with chronic myeloid leukemia. The outcome to be measured is the response to treatment based on genetic analysis and blood cell count, and the side effects. The study is located in Houston, Texas, United States. The...
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In a nutshell This phase 3 trial aims to determine the effect of blinatumomab compared to standard chemotherapy in treating patients with B-cell acute lymphoblastic leukemia after a relapse (return of cancer after a period of improvement). The outcome to be measured is the survival rate over 10 years. The details Acute lymphoblastic leukemia...
Read MoreIn a nutshell This phase 3 trial aims to evaluate the efficacy of gilteritinib as a maintenance therapy for acute myeloid leukemia (AML) patients to prevent cancer returning. The main outcomes to be investigated are relapse free survival and overall survival. The details Gilteritinib is a kinase inhibitor. It works by binding and inhibiting...
Read MoreIn a nutshell This phase 3 trial aims to evaluate the efficacy and safety of AG-221 as a treatment for older patients with late stage IDH2 mutated acute myeloid leukemia (AML). The main outcome to be investigated is overall survival. The details Mutations in the isocitrate dehydrogenase enzyme 2 (IDH2) are present in roughly 15% of AML...
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In a nutshell This study analyzed the outcomes of lymphoma and chronic lymphoblastic leukemia (CLL) patients who received haplo-cord stem cell transplantation. The study concluded that this method gives higher rates of engraftment and lower rates of graft-versus-host disease (GVHD) compared to haploidentical transplant. Some background High-risk...
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Cherry Hughes** is an active, energetic 75 year old, still working in the marketing and public relations profession in Great Britain. Her life is filled with friends and fun. “I love cooking and eating out. I am deeply interested in politics. I love music …I go to jazz clubs. I love going to France …I have a little apartment...
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In a nutshell This study examined whether chromosomal abnormalities at diagnosis can predict treatment outcomes with TKIs in chronic myeloid leukemia (CML). Researchers reported similar long-term treatment outcomes in patients with and without chromosomal abnormalities at diagnosis. Some background CML is a disease in which the bone marrow makes...
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