In a nutshell This study looked at the evidence for the safety of ibrutinib (Imbruvica) in the treatment of patients with chronic lymphocytic leukemia (CLL) or mantle cell lymphoma (MCL). Researchers found that this drug is safe to use in these patients. Some background Leukemia and lymphoma are types of cancer of the bone marrow. They can lead to...
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In a nutshell This study looked at the safety and effectiveness of switching from original brand imatinib (Gleevec) to generic imatinib in chronic myeloid leukemia (CML). The study found that switching from branded to generic imatinib is a safe option in these patients. Some background New medications on the market have a patent by their...
Read MoreIn a nutshell This study aimed to compare the safety and effectiveness of duvelisib (Copiktra) and ofatumumab (Arzerra) in patients with relapsed or refractory chronic lymphocytic leukemia. This study concluded that duvelisib was an effective treatment option for these patients. Some background Chronic lymphocytic leukemia (CLL) is the most common...
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In a nutshell This study looked at the safety and effectiveness of using stem cells from the umbilical cord to reduce the return of disease in acute leukemia. Researchers found that stem cells from the umbilical cord were more effective than stem cells from other areas in the treatment of acute leukemia. Some background Refractory acute leukemia (rAL)...
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In a nutshell This study looked at the safety and effectiveness of arsenic trioxide (Trisenox; ATO) and all-trans-retinoic acid (Vesanoid; ATRA) in the treatment of relapsed (cancer return) acute promyelocytic leukemia (APL). Researchers found that long-term ATO-ATRA treatment may improve the outcomes of these patients. Some background Acute...
Read MoreIn a nutshell This study compared the safety and effectiveness of two different treatment plans for patients with T-cell acute lymphoblastic leukemia (ALL). The study found that different medications and dosages used in both treatment plans improved survival in patients with ALL. Some background Acute lymphoblastic leukemia is a cancer of the...
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In a nutshell The study looked at the safety and effectiveness of combining different chemotherapy drugs followed by stem-cell transplant for the treatment of unresponsive acute myeloid leukemia (AML). Researchers found that this method was safe and effective in the patients studied. Some background Acute myeloid leukemia is a cancer of the bone...
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In a nutshell This study looked at the risk of osteonecrosis (ON – bone death/damage) as a treatment complication in children with acute lymphoblastic leukemia (ALL). The study found that older age and steroid drugs were risk factors for ON in the treatment of ALL. Some background Acute lymphoblastic leukemia (ALL) is a cancer of the bone marrow...
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In a nutshell This study looked at the risk of anxiety and depression in patients who survived acute lymphoblastic leukemia (ALL) in childhood. The study found that factors such as fatigue, poor sleep, and mental function increased the risk of anxiety and depression in these patients. Some background Acute Lymphoblastic Leukemia (ALL) is a cancer...
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In a nutshell This study looked at updates on the safety and effectiveness of gemtuzumab ozogamicin (Mylotarg) in the treatment of acute myeloid leukemia (AML). Researchers found that a low dose of gemtuzumab ozogamicin in addition to standard chemotherapy was safe and effective in the treatment of AML. Some background Acute myeloid...
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In a nutshell This study aimed to evaluate the safety and effectiveness of combination treatment using chlorambucil, rituximab, and lenalidomide for patients with chronic lymphocytic leukemia. This study concluded that this combination followed by lenalidomide alone leads to outcomes comparable to other established combination treatments for these...
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In a nutshell This study looked at the effect of early monitoring on disease progression and treatment cost in patients with chronic myeloid leukemia (CML). Researchers found that patients with CML who are monitored earlier may have better outcomes and lower treatment costs. Some background Chronic Myeloid Leukemia (CML) is a progressive cancer...
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