In a nutshell This study aimed to investigate the ending of imatinib treatment in patients with chronic-phase chronic myeloid leukemia who had at least 2 years of deep molecular response from imatinib first line treatment. This study concluded that the duration of treatment and residual...
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In a nutshell This study aimed to investigate if the combination of cladribine, cytarabine, and granulocyte colony-stimulating factor (G-CSF) could act as salvage treatment for patients with relapsed or unresponsive acute myeloid leukemia. This study concluded that this treatment was safe and effective in...
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In a nutshell This study aimed to identify an effective and safe chemotherapy for children with acute myeloid leukemia (AML). This study concluded that clofarabine during remission induction may reduce the need for other treatments which cause side effects in these patients. Some background Clofarabine...
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In a nutshell This study aimed to investigate the safety of a combination of olaptesed pegol, bendamustine, and rituximab in patients with chronic lymphocytic leukemia. This study concluded that olaptesed pegol was safe and the combination was effective in these...
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In a nutshell This study aimed to investigate if combining ibrutinib and venetoclax would enable the eradication of chronic lymphocytic leukemia and allow therapy to end. This study concluded that this combination was safe and effective in these patients and that therapy cessation was achieved for some...
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In a nutshell This trial is investigating the effectiveness of adding chemotherapy drug venetoclax to a standard chemotherapy treatment for patients with acute myelogenous leukemia (AML). The main outcome for this study would be the maximum amount of the drug that gives the most benefits to patients and the effectiveness of the drug. This study...
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In a nutshell This trial is examining the effectiveness of crenolanib after salvage chemotherapy for relapsed or unresponsive acute myeloid leukemia (AML) with FLT3 activating mutations. The main outcome would be survival without complications from leukemia 3 years after the treatment has finished. The details AML is a type of blood...
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In a nutshell This study investigated female fertility preservation (FFP) in cancer patients. They found that FFP should be discussed with all women of reproductive age undergoing cancer treatment. Some background Cancer can have many negative effects on patient health. Infertility is a particular concern for younger female patients. Pregnancy rates...
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In a nutshell This study aimed to compare the effectiveness of an adult treatment regimen and a pediatric-inspired regimen in adult patients with acute lymphocytic leukemia. This study concluded that the pediatric-inspired regimen is superior to the adult treatment regimen for these patients. Some background Many...
Read MoreIn a nutshell This study analyzed the outcomes of allogeneic stem cell transplantation (alloSCT) in patients with acute myeloid leukemia (AML) who had experienced multiple relapses. The main finding was that those who received alloSCT while in complete remission for at least the third time had the best survival. Some background Complete...
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In a nutshell This study looked at the effectiveness of busulfan (Busilvex) and fludarabine (Fludara) before transplant in the treatment of older patients with acute myeloid leukemia (AML). Researchers found that this treatment was safe and effective in these patients. Some background Acute myeloid leukemia is a cancer of the bone marrow. It...
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In a nutshell This study compared the safety and effectiveness of quizartinib compared to chemotherapy in the treatment of relapsed or unresponsive acute myeloid leukemia (AML). Researchers found that quizartinib was safer and more effective than chemotherapy in these patients. Some background Acute myeloid leukemia (AML) is a cancer of the bone...
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