In a nutshell This study aimed to further investigate the safety and tolerability of midostaurin plus chemotherapy in patients with newly diagnosed FLT3 mutation-positive acute myeloid leukemia. This study concluded that this combination was safe and effective in these patients. Some background FLT3 is a mutation...
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In a nutshell This study aimed to investigate the association between total body irradiation and further breast cancer diagnosis in patients treated with blood or marrow transplantation for leukemia-lymphoma. This study concluded that there is an association between the total body irradiation and an increased risk of breast cancer in certain...
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In a nutshell This study aimed to investigate the safety and effectiveness of flumatinib (HHGV678) compared to imatinib (Gleevec) in patients with chronic-phase chronic myeloid leukemia. This study concluded that flumatinib was a safe and more effective than imatinib in these patients. Some background...
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CLL or Chronic Lymphocytic Leukemia results from a mutation in B lymphocytes, a type of white blood cell that develops in the bone marrow. B-cells produce antibodies, an important part of the immune system. CLL can be slow growing, with small slow changes in the blood counts over years or fast growing, where cancerous B-lymphocytes crowd out the bone...
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In a nutshell This trial was carried out to assess the effectiveness of azacitidine (Vidaza) in combination with venetoclax (Venclexta) for the treatment of untreated acute myeloid leukemia (AML) in older adults. The authors concluded that this combination prolonged survival and induced more remissions in these patients. Some...
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In a nutshell The study evaluated outcomes of sorafenib (Nexavar) maintenance therapy after allogeneic hematopoietic stem cell transplantation (alloHSCT) in patients with acute myeloid leukemia (AML) carrying FLT3-ITD mutation (abnormal gene). The authors found that this therapy was effective and tolerable after aHSCT in such patients. Some...
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In a nutshell This study aimed to investigate the safety and effectiveness of nelarabine (Arranon) in young patients with newly diagnosed T cell acute lymphoblastic leukemia. This study concluded that nelarabine improves disease-free survival for these patients without increasing toxicity. Some background A...
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In a nutshell This study aimed to investigate the long-term effectiveness of the combination of ibrutinib, bendamustine, and rituximab in relapsed/unresponsive chronic lymphocytic leukemia/small lymphocytic lymphoma. This study concluded that this combination was safe and effective in the long-term in these...
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In a nutshell This study aimed to investigate if the combination of dasatinib and decitabine was safe and effective in patients with advanced chronic myeloid leukemia. This study concluded that this treatment is safe and effective in these patients. Some background Treatment of advanced-phase chronic myeloid...
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In a nutshell This study aimed to investigate the safety and effectiveness of the combination of obinutuzumab (Gazyva), ibrutinib (Imbruvica) and venetoclax (Venclexta) in patients with chronic lymphocytic leukemia. This study concluded that this treatment is safe and effective for these patients. Some...
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In a nutshell This study aimed to investigate if postinduction central nervous system (CNS; brain and spine) protection with intrathecal (injection into the spine) triple therapy (ITT) would improve the outcomes for pediatric patients with acute lymphoblastic leukemia (ALL) when compared to intrathecal methotrexate (MTX; Otrexup)...
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In a nutshell The study evaluated outcomes of combining ofatumumab (Arzerra) with hyper-CVAD chemotherapy in patients with Philadelphia chromosome (Ph)-negative CD20-positive B-cell acute lymphoblastic leukemia (B-ALL). The authors found that the combination was safe and effective in such patients. Some background Philadelphia chromosome (Ph) is a...
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