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Treating patients with high risk acute promyelocytic leukemia (APL) with ATRA, arsenic trioxide and gemtuzumab ozogamicin

Posted by on May 10, 2020 in Leukemia | 0 comments

In a nutshell The study evaluated the effectiveness and safety of combing all-trans retinoic acid (ATRA; Vesanoid), arsenic trioxide (ATO; Trisenox), and gemtuzumab ozogamicin (GO; Milotarg) in treating patients with high risk (HR) acute promyelocytic leukemia (APL). The authors found that the combination therapy was effective and well...

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The effects of continued blinatumomab therapy in adult patients with relapsed/refractory acute lymphoblastic leukemia

Posted by on May 3, 2020 in Leukemia | 0 comments

In a nutshell The study evaluated treatment outcomes in patients with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL) who continued blinatumomab (Blincyto; BL) after initial therapy. The authors found that long-term BL therapy can improve survival in these patients. Some background 45% of adults with ALL experience R/R...

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The link between treatment outcomes and quality of life in patients with chronic myeloid leukemia under tyrosine kinase inhibitor therapy

Posted by on May 3, 2020 in Leukemia | 0 comments

In a nutshell The study examined whether health-related quality of life (HRQoL) relates to the molecular response (MR) to tyrosine kinase inhibitors (TKIs) in patients with chronic-phase chronic myeloid leukemia (CP-CML). The authors found that improved MR had differential effects on HRQoL in such patients. Some background TKIs are a treatment used...

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Long-term effects of ofatumumab and chlorambucil in previously untreated patients with chronic lymphocytic leukemia

Posted by on Apr 25, 2020 in Leukemia | 0 comments

In a nutshell The study evaluated the long-term effectiveness and safety of Ofatumumab (Arzerra) and chlorambucil (Leukeran) (CHL) in patients with previously untreated chronic lymphocytic leukemia (CLL). The authors found that the combination therapy safely improved clinical outcomes in such patients in 5 years, compared to chlorambucil alone. Some...

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Hemopoietic stem cell transplant after chimeric antigen receptor T-cell therapy in patients with relapsed/refractory B-cell acute lymphoblastic leukemia

Posted by on Apr 25, 2020 in Leukemia | 0 comments

In a nutshell This study aimed to investigate if a hemopoietic stem cell transplant should be carried out after chimeric antigen receptor T cell therapy in patients with B-cell acute lymphoblastic leukemia.   This study concluded that this treatment path led to high event-free survival in these patients.   Some background...

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The effect of stomach acid suppressants on the safety and effectiveness of dasatinib in patients with chronic myeloid leukemia

Posted by on Apr 21, 2020 in Leukemia | 0 comments

In a nutshell This study aimed to investigate the influence of stomach acid suppressants on dasatinib treatment in patients with chronic-phase chronic myeloid leukemia.   This study concluded that these drugs did not influence dasatinib treatment in this patient group.   Some background...

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