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Long-term outcomes of allogeneic stem cell transplantations in young high-risk CLL patients

Posted by on Oct 5, 2017 in Leukemia | 0 comments

In a nutshell This study examined predictors of outcomes with stem cell transplantation from a donor (allo-SCT) for chronic lymphocytic leukemia (CLL). Researchers reported good long-term outcomes for young high-risk CLL patients treated with allo-SCT. Patients with matched sibling donors showed better outcomes compared to those with matched unrelated...

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10-years on: Imatinib as a first-line therapy for CML

Posted by on Oct 3, 2017 in Leukemia | 0 comments

In a nutshell This study examined treatment combinations involving imatinib (Gleevec) for chronic myeloid leukemia (CML). Researchers concluded that treatment with standard-dose imatinib achieved a survival comparable to that of the general population. Patient disease factors affected outcomes more than initial treatment selection. Some background...

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Liver dysfunction at diagnosis can impact survival

Posted by on Oct 3, 2017 in Leukemia | 0 comments

In a nutshell This study examined whether the presence of liver dysfunction affects the outcomes of newly diagnosed chronic lymphocytic leukemia (CLL). Researchers concluded that patients with liver dysfunction at diagnosis (about 1 in 25 patients) have shorter survival compared to patients with normal liver function. Some background In CLL, high...

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How can cytogenetic-risk status affect the outcome of cell transplants for acute myeloid leukaemia patients?

Posted by on Oct 1, 2017 in Leukemia | 0 comments

In a nutshell This study aimed to investigate the post-hematopoietic (stem) cell transplant outcomes for older patients with AML in their second complete remission. This study concluded that hematopoietic cell transplant is a good treatment option, especially for patients with favorable- or intermediate-cytogenetic risk status.  Some background...

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The use of CAR-T cell therapy for AML

Posted by on Sep 26, 2017 in Leukemia | 0 comments

In a nutshell This study reviewed the use of CAR-T cell therapy, a new type of immunotherapy, for acute myeloid leukemia (ALL). Some background Chemotherapy is often the first-line treatment for AML. In cases of a relapse (return of the disease), alternative treatment options are usually explored. This is because many patients develop a resistance...

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The impact of imatinib on male fertility

Posted by on Sep 26, 2017 in Leukemia | 0 comments

In a nutshell This study examined whether imatinib (Gleevac) affects the fertility of men with chronic myeloid leukemia (CML). Researchers concluded that imatinib reduced sperm density, sperm count, sperm survival and activity when compared to healthy control participants.  Some background CML has three phases: chronic, accelerated, and...

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Management of CLL that has progressed following ibrutinib

Posted by on Sep 26, 2017 in Leukemia | 0 comments

In a nutshell This study reviewed evidence on patients with chronic lymphocytic leukemia (CLL) that stop responding to ibrutinib (Imbruvica) therapy. Some background Tyrosine kinase inhibitor therapy is a targeted therapy that blocks signals needed for tumors to grow. This includes the Bruton tyrosine kinase inhibitor ibrutinib. Ibrutinib blocks a...

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Side effects of ibrutinib and idelalisib treatment

Posted by on Sep 22, 2017 in Leukemia | 0 comments

In a nutshell In this review, the authors look at the most common adverse events related to ibrutinib and idelalisib, B-cell inhibitors. The study concluded that both ibrutinib and idelalisib are effective at treating B-cell cancers, and the side effects are within a normal range compared to other similar treatments. Some background Ibrutinib and...

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