In a nutshell This study assessed the safety and effectiveness of a new formulation of exenatide compared to sitaglipitin in patients with sub-optimal blood sugar control taking metformin. This study concluded that exenatide reduced blood sugar levels over 3 months more effectively than sitaglipitin. Some background There are many blood...
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Can GLP-1 RAs reduce the risk of heart attacks and death?
In a nutshell This study examined the effects of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) on death, heart attacks, stroke, and heart failure in people with type 2 diabetes (T2D). They determined that GLP-1 RAs were associated with a reduced risk of heart attacks and death from cardiovascular causes. Some background Glucagon-like...
Read MoreIs there a link between SGLT2 inhibitors and diabetic ketoacidosis?
In a nutshell This study investigated the link between sodium/glucose transporter 2 (SGLT2) inhibitors and diabetic ketoacidosis (DKA). They found an increased number of cases of DKA in people treated with SGLT2 inhibitors. Some background SGLT2 is a protein in the kidneys that is important in controlling blood glucose levels. It allows glucose to...
Read MoreIs there a benefit to switching to insulin pump therapy in patients with type 1 diabetes?
In a nutshell This study investigated the effects of switching from multiple insulin injections to a continuous insulin pump in patients with type 1 diabetes. They concluded that insulin pump therapy effectively improved blood sugar control in patients with type 1 diabetes who switched from multiple daily insulin injections. Some background...
Read MoreDoes bariatric surgery improve disease management in obese patients with type 2 diabetes?
In a nutshell This study investigated if combining bariatric surgery with medical therapy was more effective in treating type 2 diabetes in obese patients. The authors concluded that bariatric surgery in combination with medical therapy was more effective in improving diabetes symptoms in these patients. Some background Bariatric surgery is a...
Read MoreFDA News Releases and Signing Up for Alerts
You may not know this but you can get warnings from the FDA on problems with prescription medications and over-the-counter drugs. For example, on August 11, a FDA News Release issued this warning about over-the-counter liquid vitamins that are given to young children and those who cannot swallow pills. “The U.S. Food and Drug Administration is...
Read MoreCan a bionic pancreas effectively provide day-to-day glycemic control in patients with type 1 diabetes?
In a nutshell This study investigated if a bionic pancreas, that releases insulin and glucagon (bihormonal), could improve glycemic (blood sugar) control in patients with type 1 diabetes. They found that the bionic pancreas was more effective than a conventional insulin pump in monitoring and managing glycemia in these patients. Some background...
Read MoreDoes IDegLira improve outcomes in patients with uncontrolled type 2 diabetes?
In a nutshell This study looked at the effects of IDegLira, a combination insulin drug, on outcomes in patients with uncontrolled type 2 diabetes. They found that IDegLira improved glycemic (blood sugar) control and aided weight loss in these patients. Some background The treatment of type 2 diabetes is to achieve glycemic control. This can slow...
Read MoreDo blood sugar medications increase heart attack risk in patients with diabetes receiving dialysis for kidney disease?
In a nutshell This study investigated if medications used to treat high blood sugar increased the risk of heart attack in patients with diabetes and end-stage kidney disease undergoing dialysis. This study concluded that patients taking non-insulin drugs were more likely to have a heart attack. Some background Diabetes is an illness that...
Read MoreDoes gestational diabetes increase breast cancer risk?
In a nutshell This study investigated if there is a link between gestational diabetes and a risk of developing breast cancer. This study showed that women who developed gestational diabetes in 2 or more pregnancies had an increased risk of developing breast cancer. Some background Gestational diabetes mellitus (GDM) is a condition that occurs in...
Read MoreSGLT2 inhibitors plus insulin in patients with type 2 diabetes
In a nutshell This study examined the safety and effectiveness of SGLT2 inhibitors in addition to insulin in patients with type 2 diabetes (T2D). It determined that these drugs improve glycemic control (control of blood glucose levels), but increase the risk of some side effects. Some background SGLT2 is a protein in the kidneys that is important...
Read MoreMetformin and glycemic control in overweight and obese young people with type 1 diabetes
In a nutshell This study examined the effect of metformin (Glucophage) on control of blood glucose levels (glycemic control) in overweight and obese young people with type 1 diabetes. It determined that metformin lead to slight improvements in HbA1c levels (average blood glucose over the last 3 months). Some background Overweight or obese...
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