In a nutshell This study investigated the use of different clinical factors in predicting pathological complete response to neoadjuvant chemoradiotherapy among rectal cancer patients. Some background Neoadjuvant therapy in rectal cancer refers to treatments given before surgery, such as chemotherapy and/or radiation treatments. Chemoradiation is...
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In a nutshell This study investigated the association between survival and beta-blocker use in colorectal cancer. Some background Colorectal cancer is one of the most common malignant diseases worldwide. Despite recent advances in treatments such surgery, chemotherapy and radiotherapy, survival rates among advanced colorectal cancer patients...
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In a nutshell This study analyzed data from the national cancer surveillance program in order to compare between the characteristics and outcomes of patients with colon and rectal cancer. Some background Colon and Rectal cancer are the third most common causes of cancer in the United States. The clinical presentation, diagnosis and treatment of...
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In a nutshell This study evaluated the effect of AT-rich interactive domain 3A (ARID3A) expression on colorectal cancer survival. Some background AT-rich interactive domain 3A (ARID3A) is a protein that has recently been identified as an important regulator of cell growth. Recent studies have reported that ARID3A protein levels are markedly...
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In a nutshell The current study examined whether the proteins versican and lumican were predictive of prognosis among colon cancer patients. Some background Colon cancer treatments vary depending on the type and stage of the disease. Patients with advanced cancer, which has invaded the surrounding lymph nodes, usually receive chemotherapy along...
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In a nutshell This study evaluated whether past surgery could be used to predict response to bevacizumab (Avastin) treatment among metastatic cancer patients. Some background Combined treatment with bevacizumab and chemotherapy is the standard of care for the treatment of metastatic (wide spread) colorectal cancer. Bevacizumab acts by inhibiting...
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In a nutshell This study evaluated p300 as a potential prognostic marker for colorectal cancer survival. Some background Survival of colorectal cancer patients is currently estimated according to cancer staging and lymph node involvement. However, both survival and the response to treatments vary widely between patients. Therefore, new molecules...
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In a nutshell This meta-analysis examined the risk of fatal adverse events among various advanced cancer patients receiving EGFR-targeting monoclonal antibodies. Some background A mutation causing the overproduction (termed overexpression) of epidermal growth factor receptor (EGFR), which plays a role in the creation, migration, and survival of...
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Roll Out Those Lazy, Hazy, Crazy Days of Summer Researchers, especially epidemiologists, look for patterns. And they found patterns when they looked at the places where people are most likely to get cancer. They found that there is more cancer in people living in higher latitudes, that is, closer to the arctic. So they started thinking and figuring out this...
Read MoreIn a nutshell This study evaluated the outcomes of patients with colon cancer (cancer of the large intestine) who underwent a procedure called sentinel lymph node microscopic analysis. Some background The lymphatic system is composed of lymphatic vessels and lymph nodes which drain the lymphatic fluid, and specialized cells of the immune system....
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In a nutshell This study evaluated the sexual and anorectal (the final part of the large bowel) functions after rectal cancer removal and radiotherapy. Some background The rectum is the lowest part of the large intestine, located behind the urinary bladder and nearby the nerves and structures that control sexual function. Usually, patients who...
Read MoreIn a nutshell This study evaluated whether longer waiting times to first treatment are associated with poor outcome among colorectal cancer patients. Some background Evidence exists that with some cancers, early diagnosis and treatment can dramatically improve survival. However, the association between survival and the time to treatment among...
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