In a nutshell This study investigated the best first-line therapy to add to bevacizumab (Avastin) treatment in patients with metastatic (spread to other parts of the body) colorectal cancer (mCRC). Researchers suggested that irinotecan (Camptosar) plus bevacizumab improved the outcomes of these patients. Some background Colorectal cancer is...
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In a nutshell The aim of this study was to evaluate if hepatic arterial infusion chemotherapy (HAIC) could be beneficial for patients with colorectal cancer (CRC) that has spread to the liver (liver metastasis; LM). The study found that HAIC improved the outcome of these patients. Some background CRC is one of the most common types of cancer...
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In a nutshell This study evaluated the impact of non-drug therapy on the quality of life (QoL) of patients with colorectal cancer (CRC). The study found that non-drug therapies such as psychological, social, and physical activities were associated with reduced anxiety, depression, and improved QoL. Some background CRC is one of the most...
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In a nutshell This study reviewed regional treatment options for patients with colorectal cancer (CRC) and liver metastases (LM; spread to the liver). Some background CRC is the third most common cancer in the world. The most common organ where the cancer spreads is the liver. Surgery is the standard treatment for LM....
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In a nutshell The aim of this study was to investigate the role of chemotherapy (CT) after surgery in patients with rectal cancer. The study suggests that CT after surgery could improve patient outcomes. Some background Rectal cancer can be treated with surgery to remove the tumor. In general, patients are given CT before the...
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In a nutshell The aim of this study was to evaluate 2 treatment options for patients with colorectal cancer (CRC) that has spread to the liver. The study found that patients who underwent associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) had better outcomes compared to those who had 2-stage hepatectomy...
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In a nutshell This study is searching for participants with advanced solid tumors including colorectal cancer to examine the safety and effectiveness of experimental drug avapritinib (AYVAKIT). The main outcomes to be measured are the response to treatment and side effects. This trial is being conducted in Texas, US. The details Some cancers grow as a...
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In a nutshell The aim of this study was to evaluate the impact of adding oxaliplatin (Eloxatin) to the chemotherapy regimen tegafur uracil (UFT)/leucovorin (LV; folinic acid) for patients that had surgery for colorectal cancer (CRC). The study found that the addition of oxaliplatin to UFT/LV improved patient outcomes. Some background CRC can...
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In a nutshell The aim of this study was to compare the outcome of laparoscopic (keyhole surgery) and open surgery for patients with rectal cancer. The study found no difference in patient outcomes between laparoscopic and open surgery groups. Some background Localized rectal cancer can be treated by surgical removal of the tumor. Usually, patients...
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In a nutshell This study investigated the outcomes of patients with rectal cancer who were followed up with the watch and wait method after chemoradiotherapy (CRT). Researchers suggested that this strategy can effectively identify patients who can have a less frequent follow-up if they maintain response for the first 3 years...
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In a nutshell The aim of this study was to evaluate the urinary and sexual function of patients following 2 types of rectal cancer surgery. The study found that in men, robotic surgery resulted in better urinary and sexual function. Some background Rectal cancer can be treated by surgical removal of the tumor. Therapy for rectal cancer has improved...
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In a nutshell This study evaluated the benefit of adding hyperthermic intraperitoneal chemotherapy (HIPEC) to cytoreductive surgery (CS) for the treatment of colorectal cancer (CRC) that has spread to the peritoneum (the lining of the abdomen that covers all abdominal organs). The study found that HIPEC added to CS did not improve the outcomes of...
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