In a nutshell This phase 1/2 trial is examining the effectiveness of a new immunotherapy in the treatment of patients with advanced colorectal cancer (CRC). The main outcome to be measured will be tumor response to the treatment. This study is being conducted in Texas, USA. The details CRC is the third most common cancer worldwide. The 5-year...
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In a nutshell This study investigated the survival outcomes in patients with rectal cancer after surgery with and without radiation therapy (RT). Researchers suggested that RT after surgery is associated with improved outcomes. Some background Rectal cancer is one of the most common cancers worldwide. Between 15 to 20% of patients present metastatic...
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Nanodrugs have been around for some time. In fact, over 250 drugs using nanotechnology that have been approved by the FDA and are in clinical use. The name nanodrug or nanopharmaceuticals refers to the size of the particle that is created to house the medication. A nano is very tiny: nanoparticles are between 1 and 100 nanometers in at least one of its...
Read MoreIn a nutshell This phase 1/2 trial will investigate the safety of 9-ING-41, for treatment-resistant cancers. The main outcome will be the number of treatment-related adverse events (TRAEs). This trial is recruiting in the United States. The details Some cancers may not respond to conventional treatment. Treatment-resistant cancers are called...
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In a nutshell This phase 2 trial is examining the effectiveness of FOLFOX chemotherapy to treat patients with rectal cancer, without surgery and radiation. The main outcome to be measured will be the tumor response to the treatment. This study is being conducted in New York, US. The details This year an estimated 44,180 people will be diagnosed with...
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In a nutshell This phase 1 study will investigate the dose range and effectiveness of an experimental drug, XmAb23104, in the treatment of advanced colorectal cancer and other solid tumors. The main outcome will be the safety and tolerability of XmAb23104. This trial is recruiting in Georgia, Texas, and Virginia, the United States. The details...
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In a nutshell This study investigated the impact of starting chemotherapy treatment immediately after colon cancer surgery. Researchers suggested that this option is safe. Some background Colorectal cancer is the third most common cancer worldwide. The standard treatment is surgery and chemotherapy. However, colon cancer surgery is associated with a...
Read MoreIn a nutshell This phase 2 trial is examining the effectiveness and safety of navarixin (MK-7123) in combination with pembrolizumab (Keytruda) in patients with colorectal cancer (CRC). The main outcome to be measured will be the objective response rate (ORR; tumor shrinkage or disappearance). The details A treatment option for patients with...
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In a nutshell This study investigated the outcomes of stage 4 colorectal cancer patients who received surgery. Researchers suggested that surgery in these patients is associated with an improved 5-year survival rate. Some background Colorectal cancer is the second leading cause of death in the US. A significant number of patients presents have stage 4...
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In a nutshell This study investigated the effectiveness of local vs radical surgery in patients with rectal cancer. Researchers suggested that local surgery is associated with better outcomes in certain patients with early cancers. Some background Colorectal cancer is the third most common cancer in the US. The standard treatment options for these...
Read MoreIn a nutshell This phase 1b trial is examining the effectiveness and safety of cibisatamab in combination with atezolizumab (Tecentriq) after treatment with obinutuzumab (Gazyva) in patients with previously treated metastatic colorectal carcinoma (mCRC). The main outcomes to be measured will be side effects and...
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In a nutshell This study investigated the risk of pelvic fracture (PF) in patients with rectal cancer who received radiation therapy. Researchers suggested that there is an increased risk of PF in these patients. Some background Rectal cancer rates have been increasing, especially in younger populations. Due to improvements in medical care, survival...
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