In a nutshell This study investigated the effectiveness and safety of combining proton radiotherapy (PRT) plus carbon-ion radiotherapy (CIRT) with chemotherapy (CT) given at the same time in patients with limited-stage (LS) small cell lung cancer (SCLC). The data showed that PRT plus CIRT with CT given at the same time was effective with manageable side...
Read MoreType of lung cancer-Small cell lung carcinoma (SCLC) Posts on Medivizor
Searching for patients with unresponsive breast cancer to trial an experimental treatment.
In a nutshell This trial aims to assess the safety and effectiveness of an experimental drug, CYT-0851 in the treatment of B-cell and solid tumors, including breast cancer, that have come back or are no longer responsive to treatments. The main outcomes to be measured are the side effects and the overall response to the treatment....
Read MoreShould durvalumab be considered a first-line treatment for extensive small cell lung cancer?
In a nutshell This study looked at the effectiveness of durvalumab (Imfinzi) with or without tremelimumab plus platinum-etoposide (Etopophos) (PE) versus PE-alone for the treatment of extensive-stage small-cell lung cancer (ESCLC). The authors found that durvalumab plus PE showed sustain survival improvement in these patients. Some background...
Read MoreSearching for patients with advanced lung cancer to trial a new immune treatment.
In a nutshell This trial is looking at the effectiveness, safety, and tolerability of ladiratuzumab vedotin (LV) in patients with advanced solid tumors, including lung cancer. The main outcome to be measured in this trial is the response rate to the new drug. The details Advanced tumors have spread from the organ where they originated. These tumors...
Read MoreEvaluating lurbinectedin for unresponsive small cell lung cancer
In a nutshell This study evaluated the safety and effectiveness of an experimental treatment, lurbinectedin, in patients with small-cell lung cancer (SCLC) after unsuccessful treatment with platinum-based chemotherapy. The authors found that this treatment showed promising effectiveness and manageable side effects in these...
Read MoreTreating advanced and reoccurring small cell lung cancer with pembrolizumab
In a nutshell This study wanted to find out if pembrolizumab (Keytruda) treatment works in patients with small-cell lung cancer who have received at least two other types of cancer treatment before. The study found that treatment with pembrolizumab was effective and well tolerated in these patients. Some background Small-cell lung cancer (SCLC)...
Read MoreCan neutrophil to lymphocyte ratio guide treatment choice in small cell lung cancer?
In a nutshell This study investigated if neutrophil to lymphocyte ratio (NLR) can be used to chose a first-line treatment in patients with small-cell lung cancer (SCLC). They found that NLR could be used to choose a treatment for these patients. Some background Lung cancer is a common cancer with poor prognosis. Small cell lung cancer (SCLC) is a...
Read MoreSearching for patients with advanced solid tumors to test a new medication
In a nutshell This phase 1/2 trial will investigate the safety of ALKS 4230 (ALKS) in advanced solid tumors. The main outcome will be adverse events and toxicities and disease control. This trial is recruiting at multiple locations in the US and Canada. The details The treatment options for advanced cancer are limited. New drugs are...
Read MoreSearching for patients with lung cancer to trial a combination of immunotherapy and chemoradiation
In a nutshell This trial aims to investigate the safety and effectiveness of durvalumab (Imfinzi) combined with chemotherapy and radiation in patients with advanced lung tumors. The main outcome that will be measured is if there are any side effects and survival without signs of disease. The details Duravalumab is an anti-cancer...
Read MoreSearch for patients with relapsed or unresponsive small cell lung cancer to try a treatment combination
In a nutshell This study wants to find out how well talazoparib (Talzenna) and temozolomide (Temodal) work for treating patients with small cell lung cancer that has come back after or was unresponsive to initial chemotherapy. The main outcome that will be measured is how long the patients go before the cancer grows. The study is...
Read MoreLooking for patients with advanced lung cancer to test a new drug
In a nutshell This phase 1 study will investigate the dose range and effectiveness of an experimental drug, XmAb23104, in the treatment of advanced lung cancer and other solid tumors. The main outcome will be the safety and tolerability of XmAb23104. This trial is recruiting in Georgia, Texas, and Virginia, the United States. The details Advanced...
Read MoreEffectiveness of atezolizumab plus chemotherapy in small-cell lung cancer
In a nutshell This article investigated the safety and effectiveness of atezolizumab (Tecentriq) plus chemotherapy for the treatment of extensive-stage small-cell lung cancer (SCLC). The authors concluded that this treatment is safe and can improve survival of these patients. Some background Patients with extensive-stage SCLC...
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