In a nutshell This study compared the effectiveness of regular myeloablative conditioning (MAC; chemotherapy that kills cells in the bone marrow, including cancer cells before a transplant) with reduced-intensity conditioning (RIC) in the treatment of chronic myeloid leukemia. Researchers found that RIC had similar effectiveness and less risk of...
Read MoreType of leukemia-Chronic Myeloid Leukemia (CML) Posts on Medivizor
Survival from transplant of donor bone marrow versus donor blood sample in leukemia treatment
In a nutshell This study compared the safety and effectiveness of donor peripheral blood (PB) with bone marrow (BM) transplant in the treatment of leukemia. Researchers found that bone marrow transplants are safer and more effective in the treatment of leukemia. Some background Leukemia is a cancer of the bone marrow. It may lead to abnormal immune...
Read MoreUsage and safety of drug treatment in chronic myeloid leukemia
In a nutshell This study aimed to assess the usage and safety of biological treatment to treat chronic myeloid leukemia (CML). Researchers found that nilotinib (Tasigna) has a better profile as a first-line drug in the treatment of CML. Some background Chronic myeloid leukemia is a cancer of the bone marrow. This leads to abnormal immune...
Read MoreDo ACE inhibitors help with anthracycline-induced cardiotoxicity in leukemia and lymphoma?
In a nutshell This study aimed to investigate if enalapril influences anthracycline-induced cardiotoxicity in children with leukemia and lymphoma. This study concluded that enalapril has a role in reducing anthracycline-induced cardiotoxicity in these patients. Some background Anthracyclines are a class of chemotherapy drugs that can be used for...
Read MoreThe safety and effectiveness of bosutinib in patients with chronic myeloid leukemia
In a nutshell This study looked at the safety and effectiveness of bosutinib (Bosulif) in the treatment of chronic myeloid leukemia (CML). Researchers found that bosutinib was effective in patients who have failed other similar drug treatments. Some background Chronic myeloid leukemia (CML) is a cancer of the bone marrow. This can lead to abnormal...
Read MoreWhole body vibration during chemotherapy for leukemia and lymphoma
In a nutshell This study examined the effectiveness of vibration therapy on patients receiving chemotherapy for leukemia and lymphoma. Researchers found that vibration therapy improved daily function in these patients. Some background Exercise is proven to be effective in improving outcomes of patients with cancer. Chemotherapy treatment can make...
Read MoreSymptom burden for patients with chronic myeloid leukemia treated with tyrosine kinase inhibitors
In a nutshell This study aimed to investigate the symptom burden on patients with chronic phase chronic myeloid leukemia (CP-CML) who were treated with second or third generation tyrosine kinase inhibitors. This study concluded that the side effects of this treatment may affect the quality of life for these patients. Some background Chronic myeloid...
Read MoreComparing infection-related healthcare resource utilization and costs for patients with chronic myeloid leukemia patients treated with tyrosine kinase inhibitors
In a nutshell This study aimed to compare healthcare resource utilization and costs associated infections in patients with chronic myeloid leukemia patients receiving dasatinib and nilotinib. This study concluded that dasatinib use is associated with higher healthcare resource utilization and health care costs compared to nilotinib due to...
Read MoreEvaluating nilotinib as a consolidation therapy for patients with chronic myeloid leukemia
In a nutshell This study aimed to evaluate the effectiveness of nilotinib as a consolidation therapy for patients with chronic myeloid leukemia who had achieved a major response with imatinib. This study concluded that nilotinib led to safer, deeper responses in these patients. Some background Imatinib (Gleevec) is a tyrosine kinase inhibition (TKI)...
Read MoreCan tyrosine kinase inhibitors influence survival rates in chronic phase chronic myeloid leukemia?
In a nutshell This study aimed to investigate the side effects of tyrosine kinase inhibitors and their impact on outcomes in chronic-phase chronic myeloid leukemia patients. This study concluded that severe side effects from tyrosine kinase inhibitors can cause decreased survival rates in these patients. Some background Tyrosine kinase inhibitors...
Read MoreCan tyrosine kinase inhibitor treatment be stopped in CML patients with deep molecular response?
In a nutshell This study aimed to define the conditions necessary for stopping tyrosine kinase inhibitor treatment in patients with chronic myeloid leukemia. This study concluded that patients who maintain a deep molecular response have good molecular relapse-free survival and can be considered for treatment discontinuation. Some...
Read MoreCan chronic myeloid leukemia patients discontinue dasatinib after a year of deep molecular response?
In a nutshell This study aimed to investigate if dasatinib could be successfully discontinued in chronic myeloid leukemia patients who were receiving it as a second line treatment after a year of deep molecular response. This study concluded that it was possible to discontinue dasatinib use in this group of patients. Some background Imatinib...
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