Type of leukemia-Chronic Myeloid Leukemia (CML) Posts on Medivizor
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Type of leukemia-Chronic Myeloid Leukemia (CML) Posts on Medivizor

Is stopping nilotinib treatment safe in patients with chronic myelogenous leukemia that have achieved a stable response?

Posted by on Oct 12, 2019 in Leukemia | 0 comments

In a nutshell This study aimed to investigate the safety and effectiveness of stopping nilotinib treatment in patients with chronic-phase chronic myelogenous leukemia.  This study concluded that stopping nilotinib after two years of consolidation treatment was safe and effective.  Some background...

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Searching for patients with chronic myeloid leukemia to try a new combination of targeted treatments.

Posted by on Jun 29, 2019 in Leukemia | 0 comments

In a nutshell This study is searching for patients with chronic myeloid leukemia (CML) to try a new drug ruxolitinib (NSC-752295) with BCR-ABL Tyrosine Kinase Inhibitors. The main outcome that will be measured is the rate of significant reduction of the BCR-ABL marker. This trial is recruiting across the United States. The details BCR-ABL is a protein...

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Looking for patients with Ph+ or BCR-ABL+ acute lymphoblastic leukemia to test a treatment combination

Posted by on Jun 14, 2019 in Leukemia | 0 comments

In a nutshell This phase 2 trial is evaluating the effectiveness of ponatinib (Iclusig) plus chemotherapy for patients with acute lymphoblastic leukemia (ALL) that is positive for the Philadelphia chromosome (Ph+) or the BCR-ABL gene (BCR-ABL+). The main outcome to be measured will be the number of patients who respond to treatment. This study is...

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Evaluating first-line imatinib for elderly patients with chronic myeloid leukemia

Posted by on May 28, 2019 in Leukemia | 0 comments

In a nutshell This study compared the effects of age and treatment dose for imatinib (Gleevec) in elderly versus younger patients with chronic myeloid leukemia (CML). This study concluded older patients had similar responses to therapy compared to younger patients. Some background Tyrosine kinase (TK) inhibitors are the standard therapy for chronic...

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Evaluating the risk of heart side effects of bosutinib in patients with chronic myeloid leukemia

Posted by on May 26, 2019 in Leukemia | 0 comments

In a nutshell This study evaluated the effects of bosutinib (Bosulif) on the heart in patients with chronic myeloid leukemia (CML). This study concluded that bosutinib was associated with heart-related side effects, particularly in high-risk patients. Some background Previous studies have shown that bosutinib is effective and well-tolerated. However,...

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Rate of deep molecular response in chronic myeloid leukemia treated with nilotinib

Posted by on Apr 15, 2019 in Leukemia | 0 comments

In a nutshell This study aimed to investigate the rate of deep molecular response in patients with newly diagnosed chronic myeloid leukemia who were treated with nilotinib. This study concluded that good molecular response rates are seen in these patients. Some background Molecular response (MR) is a measure of the levels of BCR-ABL1 gene in leukemia...

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Allogenic hematopoietic stem cell transplantation as treatment for patients with BCR-ABL1-negative atypical chronic myeloid leukemia

Posted by on Feb 17, 2019 in Leukemia | 0 comments

In a nutshell This study aimed to investigate if allogeneic hematopoietic stem cell transplant is an effective treatment for atypical chronic myeloid leukemia. This study concluded that this treatment is effective in these patients. Some background Atypical chronic myeloid leukemia (aCML) and chronic neutrophilic leukemia (CNL) are cancers...

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