In a nutshell This study is searching for patients with chronic myeloid leukemia (CML) to try a new drug ruxolitinib (NSC-752295) with BCR-ABL Tyrosine Kinase Inhibitors. The main outcome that will be measured is the rate of significant reduction of the BCR-ABL marker. This trial is recruiting across the United States. The details BCR-ABL is a protein...
Read MoreType of leukemia-Chronic Myeloid Leukemia (CML) Posts on Medivizor
Kidney problems in patients being treated for chronic myeloid leukemia.
In a nutshell This study looked at the risk of kidney damage in patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitor (TKI) therapy. Researchers found that imatinib (Gleevec) was linked with greater damage to the kidney compared to nilotinib (Tasigna) or dasatinib (Sprycel) in these patients. Some background...
Read MoreLooking for patients with Ph+ or BCR-ABL+ acute lymphoblastic leukemia to test a treatment combination
In a nutshell This phase 2 trial is evaluating the effectiveness of ponatinib (Iclusig) plus chemotherapy for patients with acute lymphoblastic leukemia (ALL) that is positive for the Philadelphia chromosome (Ph+) or the BCR-ABL gene (BCR-ABL+). The main outcome to be measured will be the number of patients who respond to treatment. This study is...
Read MoreLong term outcomes of imatinib treatment for chronic myeloid leukemia
In a nutshell This study aimed to investigate the long-term outcomes of imatinib treatment in patients with CML. This study concluded that imatinib is safe and effective for long periods of use. Some background Imatinib (Gleevec) is a tyrosine kinase inhibitor (TKI) approved for the treatment of chronic myeloid leukemia (CML). TKIs...
Read MoreEvaluating first-line imatinib for elderly patients with chronic myeloid leukemia
In a nutshell This study compared the effects of age and treatment dose for imatinib (Gleevec) in elderly versus younger patients with chronic myeloid leukemia (CML). This study concluded older patients had similar responses to therapy compared to younger patients. Some background Tyrosine kinase (TK) inhibitors are the standard therapy for chronic...
Read MoreEvaluating the risk of heart side effects of bosutinib in patients with chronic myeloid leukemia
In a nutshell This study evaluated the effects of bosutinib (Bosulif) on the heart in patients with chronic myeloid leukemia (CML). This study concluded that bosutinib was associated with heart-related side effects, particularly in high-risk patients. Some background Previous studies have shown that bosutinib is effective and well-tolerated. However,...
Read MoreRate of deep molecular response in chronic myeloid leukemia treated with nilotinib
In a nutshell This study aimed to investigate the rate of deep molecular response in patients with newly diagnosed chronic myeloid leukemia who were treated with nilotinib. This study concluded that good molecular response rates are seen in these patients. Some background Molecular response (MR) is a measure of the levels of BCR-ABL1 gene in leukemia...
Read MoreAllogenic hematopoietic stem cell transplantation as treatment for patients with BCR-ABL1-negative atypical chronic myeloid leukemia
In a nutshell This study aimed to investigate if allogeneic hematopoietic stem cell transplant is an effective treatment for atypical chronic myeloid leukemia. This study concluded that this treatment is effective in these patients. Some background Atypical chronic myeloid leukemia (aCML) and chronic neutrophilic leukemia (CNL) are cancers...
Read MoreDoes cancer and stem cell transplants change taste in children?
In a nutshell This study looked at the changes in the sense of taste of children with cancer and those who received a stem cell transplant. Researchers found that taste changes in these patients were common. Some background Cancer is often treated with powerful drugs or stem cell transplant. These may have strong side effects. In children, it is...
Read MoreDoes cancer and stem cell transplants change taste in children?
In a nutshell This study looked at the changes in the sense of taste of children with cancer and those who received a stem cell transplant. Researchers found that taste changes in these patients were common. Some background Cancer is often treated with powerful drugs or stem cell transplant. These may have strong side effects. In...
Read MoreSearching for patients with blood cancer to test new stem cell transplant option
In a nutshell This phase 3 trial is comparing the safety and effectiveness of NiCord stem cell treatment with stem cells taken from the umbilical cord. The main outcome to be measured is the time to neutrophil engraftment (white blood cells accepted by the body that start to grow and make new cells) following transplantation. The details...
Read MoreUsing steroid medication to prevent stem cell transplant complications in patients with leukemia
In a nutshell This study looked at the effects of using steroid medication to prevent complications after stem cell transplant and improve survival in patients with leukemia. Researchers found that low-dose steroids improved outcomes in these patients. Some background Leukemia is a cancer of the blood-forming tissues such as the bone...
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