In a nutshell This study compared the safety and effectiveness of empagliflozin (Jardiance) with glimepiride (Amaryl) in people with type 2 diabetes (T2D). It was determined that empagliflozin reduced HbA1c more than glimepiride, and had a lower overall risk of side effects. Some background Metformin (Glucophage) is usually the first drug given...
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In a nutshell This study compared the safety of using three different medications to treat type 2 diabetes (T2D) with using only two of those medications. It was determined that using three medications was as safe as using two. Some background Control of blood glucose levels is important to prevent the long-term complications of T2D....
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In a nutshell This study investigated the long-term glycemic (blood sugar) control of type 2 diabetes patients receiving second-line medications with or without metformin (Glucophage). This study concluded that GLP-1 receptor agonists, DPP-4 inhibitors and thiazolidinedione-based therapies offer a higher chance of long-term glycemic control compared to...
Read MoreIn a nutshell This study examined the effectiveness of a weight-loss program (run in primary-care settings) on type 2 diabetes patients. The authors found that almost half of those who sustained their weight-loss were able to reverse their diabetes. Some background Many people with type 2 diabetes (T2D) are at risk of...
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In a nutshell This study investigated whether taking a protein supplement before a meal could improve the effectiveness of galvus (Vildagliptin) in people with type 2 diabetes (T2D). It found that vildagliptin was more effective when given with a protein ‘preload’. Some background Incretins are hormones that are made in the intestines...
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In a nutshell This study investigated whether semaglutide could improve the function of beta cells and glycemic control in patients with type 2 diabetes. The study concluded that once-weekly treatment with semaglutide improved beta cell function and glycemic control in these patients. Some background Beta cells are located in the pancreas and are...
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In a nutshell These guidelines examined the evidence and presented recommendations for the treatment of type 2 diabetes with oral glucose-lowering drugs. It was concluded that metformin (Glucophage) was suitable for most patients, and that some may require an additional drug. Some background Type 2 diabetes (T2D) is a progressive...
Read MoreIn a nutshell The main objective of this study was to determine the effectiveness and safety of dulaglutide (Trulicity) compared to liraglutide (Victoza) in patients with type 2 diabetes. The authors concluded that once-weekly treatment with dulaglutide was an effective and safe treatment in patients with type 2...
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In a nutshell The authors aimed to determine the safety and efficacy of saxagliptin (Onglyza) as an add-on treatment in patients with type 2 diabetes already receiving treatment with dapagliflozin (Farxiga) and metformin (Glucophage). The authors concluded that using saxagliptin as an add-on treatment for 52 weeks resulted in improvements in blood...
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In a nutshell The authors aimed to determine the effect of sitagliptin (Januvia) on major osteoporotic fractures (MOFs) in patients with type 2 diabetes. The authors concluded that sitagliptin was not associated with fractures in type 2 diabetes. Some background Patients with type 2 diabetes are at a higher risk for bone...
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In a nutshell The authors aimed to determine the effect and safety of linagliptin (Tradjenta) in patients with type 2 diabetes with liver disease. The authors concluded that linagliptin is an effective and safe treatment in patients with type 2 diabetes and liver disease. Some background Diabetes raises the risk of non-alcohol...
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In a nutshell This study examined whether alogliptin is safe and effective as an add-on therapy to metformin in patients with type 2 diabetes who require more intense control of blood glucose levels. The authors concluded that patients with type 2 diabetes who fail metformin single treatment are more likely to achieve better control...
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