In a nutshell This study evaluated the effectiveness and safety outcomes of atezolizumab (Tecentriq) given before surgery for the treatment of patients with non-small cell lung cancer (NSCLC). The data showed that atezolizumab given before surgery was safe and effective for patients with NSCLC. Some background Non-small cell lung cancer (NSCLC)...
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In a nutshell This study evaluated the effectiveness and safety of different platinum-based chemotherapy regimens given after surgery for the treatment of early-stage resected non-small cell lung cancer (NSCLC). The authors concluded that the combination of cisplatin (Platinol)-vinorelbine (Nevelbine) improved the outcomes of these patients. Also, the...
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In a nutshell This study evaluated the long-term outcomes of stereotactic ablative radiation therapy (SABR) and video-assisted thoracic surgery (VATS) for the treatment of patients with early-stage non-small cell lung cancer (NSCLC). The data showed that both SABR and VATS led to similar long-term survival outcomes. Some background...
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In a nutshell This study evaluated the benefits of postoperative radiotherapy (PORT; radiation after surgery) in patients with resectable stage III-N2 non-small-cell lung cancer (NSCLC). The data showed that PORT significantly increased survival without disease progression and reduced the risk of cancer relapse for these patients. Some background...
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In a nutshell This study investigated the optimal time interval between chemoradiotherapy (CRT) and surgery and its impact on survival outcomes in patients with locally advanced (LA) non-small-cell lung cancer (NSCLC). The data showed that surgery within 7 weeks after CRT was associated with improved survival outcomes in these patients. Some...
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In a nutshell This study compared the short-term and long-term effectiveness between video-assisted thoracic surgery (VATS) and robot-assisted thoracic surgery (RATS) for the treatment of patients with non-small cell lung cancer (NSCLC). The data showed that RATS is a good and safe technique compared with VATS in terms of short-term and long-term...
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In a nutshell This trial looked at the long-term effectiveness of gefitinib (Iressa) compared to vinorelbine (Navelbine) plus cisplatin (Platinol) for stage II-IIIA EGFR-positive non-small cell lung cancer (NSCLC). The authors found that the use of gefitinib improved disease-free survival (DFS) in these...
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In a nutshell This trial was carried out to assess the effectiveness and safety of osimertinib (Tagrisso) after surgery for EGFR-positive advanced non-small cell lung cancer (NSCLC). The trial found that this treatment improved the outcomes of patients with stage IB to IIIA EGFR-positive NSCLC that was surgically removed. Some...
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In a nutshell This study investigated the antitumor activity, safety, and survival after nivolumab (Opdivo) and chemotherapy before surgery for patients with stage IIIA non-small-cell lung cancer (NSCLC). The study showed a high rate of survival without cancer worsening among these patients. Some background NSCLC amounts to over 80% of...
Read MoreIn a nutshell This phase 3 trial is examining the effectiveness of durvalumab (Imfinzi) combined with chemotherapy vs chemotherapy alone for stage II and III non-small cell lung cancer (NSCLC) before surgery. The main outcome to be measured will be the major pathological response (mPR; 10 percent or fewer alive cancer cells...
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In a nutshell This study looked at the frequency of follow-ups after surgical treatment in patients with non-small-cell lung cancer and whether it had an effect on survival. The study concluded that more frequent surveillance was not linked to improved survival. Some background Surveillance during the post-treatment stage of cancer is a critical...
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In a nutshell This trial looked at the impact of complete lymph node dissection for patients with early stage non-small-cell lung cancer. They concluded that complete dissection of the mediastinal lymph nodes was associated with better survival rates compared to only removing a few lymph nodes for sampling. Some background Surgery to remove tumors...
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