In a nutshell This study evaluated the effectiveness and safery of administering modified (m) FOLFOXIRI (folinic acid, fluorouracil, irinotecan, oxaliplatin) chemotherapy with or without radiotherapy before surgery in patients with locally advanced rectal cancer (LARC). The results showed that this treatment was safe and improved survival without disease...
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Evaluating outcomes of laparoscopic surgery for the treatment of elderly patients over 80 years with colorectal cancer.
In a nutshell This study evaluated the short- and long-term outcomes of laparoscopic surgery (LS; keyhole surgery) for the treatment of elderly patients with colorectal cancer (CRC) aged over 80 years. The data showed that LS is a good and safe option for these patients. Some background Colorectal cancer (CRC) is one of the most common types of cancer...
Read MoreEvaluating the effectiveness and safety of total neoadjuvant therapy versus standard neoadjuvant chemoradiotherapy for locally advanced rectal cancer.
In a nutshell This study investigated the effectiveness and safety of total neoadjuvant therapy (TNT) versus standard neoadjuvant chemoradiotherapy (CRT) for the treatment of patients with locally advanced rectal cancer (LARC). The data showed that TNT was associated with improved outcomes compared with standard CRT for these patients. Some background...
Read MoreDoes adding chemotherapy after surgery for liver metastasis improve the long-term outcome of patients with colorectal cancer?
In a nutshell The study investigated the impact of adding chemotherapy after surgery to remove liver metastasis on the outcomes of patients with colorectal cancer (CRC). The study reported a significantly longer survival in patients undergoing further chemotherapy. Some background Up to 50% of patients with CRC develop...
Read MoreCan addition if oxaplatin to tegafur–uracil/leucovorin improve the outcome of patients with colorectal cancer?
In a nutshell The aim of this study was to evaluate the impact of adding oxaliplatin (Eloxatin) to the chemotherapy regimen tegafur uracil (UFT)/leucovorin (LV; folinic acid) for patients that had surgery for colorectal cancer (CRC). The study found that the addition of oxaliplatin to UFT/LV improved patient outcomes. Some background CRC can...
Read MoreComparing laparoscopic versus open surgery for patients with rectal cancer.
In a nutshell The aim of this study was to compare the outcome of laparoscopic (keyhole surgery) and open surgery for patients with rectal cancer. The study found no difference in patient outcomes between laparoscopic and open surgery groups. Some background Localized rectal cancer can be treated by surgical removal of the tumor. Usually, patients...
Read MoreHow do different types of rectal cancer surgery impact urinary and sexual function?
In a nutshell The aim of this study was to evaluate the urinary and sexual function of patients following 2 types of rectal cancer surgery. The study found that in men, robotic surgery resulted in better urinary and sexual function. Some background Rectal cancer can be treated by surgical removal of the tumor. Therapy for rectal cancer has improved...
Read MoreHigh-dose rate intraoperative brachytherapy is associated with improved outcomes in patients with high-risk rectal cancer
In a nutshell This study compared the effectiveness of electron beam radiotherapy (EBR) and high-dose brachytherapy (HDB) during surgery in patients with rectal cancer who underwent an incomplete removal of the cancer. Researchers suggested that HDB was associated with a lower risk of recurrence in these patients. Some background Colorectal...
Read MoreEvaluating surgery and chemotherapy versus chemotherapy alone for the treatment of metastatic colorectal cancer.
In a nutshell This study evaluated whether surgery of colorectal cancer (CRC) followed by chemotherapy (CT) improved the outcomes of patients with metastatic (spread) CRC compared to CT alone. The study found that there was no difference in patients' outcomes whether surgery was given or not. Some background CRC is the third most common cancer...
Read MoreCan SOX and mFOLFOX6 chemotherapies be given without radiotherapy before surgery for advanced rectal cancer?
In a nutshell This study evaluated the safety and effectiveness of two chemotherapy regimens (SOX and mFOLFOX6) before surgery for rectal cancer (RC) without radiotherapy. The study found that both regimens were safe and effective in these patients. Some background RC is commonly treated with surgery to remove the tumor. Patients with...
Read MoreLiver partition and portal vein ligation improves long-term outcomes of patients with colorectal cancer and liver metastases
In a nutshell This study investigated the long-term outcomes of patients with colorectal cancer (CRC) and liver metastases (LM; cancer spread to the liver) undergoing the ALPPS (associating liver partition and portal vein ligation) procedure. Researchers suggested that patients with LM that were unfit for surgical removal achieved positive long-term...
Read MoreWhat is the optimal timing of surgery for liver metastasis after chemotherapy in patients with colorectal cancer?
In a nutshell The study evaluated the optimal timing of surgery for colorectal cancer liver metastasis (CRLM) after chemotherapy (CT). The main finding was that surgery within 5 weeks after CT may improve patients' outcomes. Some background Chemotherapy (CT) is used before surgery to remove tumors to reduce tumor size. This is...
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