In a nutshell This review compared the efficacy and risks associated with adding oxaliplatin (OX) to fluoropyimidine (FU) chemoradiotherapy (CRT) before surgery in patients with locally advanced rectal cancer (LARC). Some background In LARC, the cancer has grown from the rectum (the lowest part of the large bowel) into surrounding...
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Evaluating the benefits of adjuvant radiotherapy after therapeutic lymphadenectomy for melanoma patients with positive lymph nodes
In a nutshell The present study compared the outcomes between patients with clinically advanced melanoma spread to the lymph nodes who underwent therapeutic lymphadenectomy (TL) alone, or TL with regional radiation therapy. Some background Melanoma spread to the nearby lymph nodes is also called lymph-node metastatic melanoma. The treatment for...
Read MoreThe right treatments are available if the correct trials are used to show that therapy is improving.
In a nutshell This editorial article published at The Journal of Clinical Oncology, expresses experts' opinion, criticizing the current practice and design of clinical trials involving patients with rectal cancer. Some background Despite improvements in treatment options, such as the addition of the platinum-based drug Oxaliplatin to...
Read MoreCan patients with rectal cancer be treated with pre-operative chemoradiation alone?
In a nutshell The present study evaluated the outcomes of patients with rectal cancer who were treated with non-operative management (NOM) after complete clinical response (cRC) to neoadjuvant chemoradiation (nCRT). Some background Rectal cancer involves the final part of the large intestine, or rectum. The first choice of treatment for...
Read MoreEvaluating the efficacy of intraoperative radiotherapy for patients with locally advanced and recurrent colorectal cancer
In a nutshell The present review evaluates the results and complications of intra-operative radiotherapy (IORT) for the treatment of patients with locally advanced (stage III) and recurrent colorectal cancer (CRC). Some background Locally advanced CRC means that the cancer has spread beyond (invaded) the lining of the large intestine...
Read MoreThe impact of 6 vs 18 months of androgen-suppression therapy, with or without Zolendronic Acid, on quality of life in men with prostate cancer
In a nutshell This clinical trial evaluated the quality of life of men with locally advanced prostate cancer (PCa) treated with Leuprorelin and radiotherapy, with or without Zolendronic Acid (ZA). Quality of life measures improved with shorter duration of Leuprorelin treatment, regardless of combining ZA. Some background Prostate cancer...
Read MoreThe impact of radiotherapy protocol on quality of life in patients with operable rectal cancer
In a nutshell This article evaluated the long-term quality of life of patients with rectal cancer, treated with either a short course of radiation before surgery, or postoperative chemo-radiation. Patients treated with pre-operative radiation reported worse sexual- and bowel-related functional outcomes. Some background In patients with...
Read MoreRecurrence rate after surgical prostate removal in men older than 70 years of age
Due to the increase in life expectancy, there exists an increasing number of patients with prostate cancer (PCA) in many populations. However, there is no consensus on screening and treatment of PCA in the medical fraternity. This paper investigated the oncological outcomes of radical prostatectomy (RP) in older men (> 70) compared to RP outcomes in...
Read MoreEvaluating quality of life and adverse effects of proton therapy in young men with prostate cancer
The present study evaluated the quality of life and adverse effects for patients younger than 60 with prostate cancer following proton therapy. The main findings were that young prostate cancer patients treated with proton therapy have great outcomes with respect to urinary and sexual function. The prostate is a small gland only found in men that has...
Read MoreRising PSA levels after radiation treatment can predict prostate cancer mortality
In a nutshell This article evaluated whether the interval to biochemical failure (IBF) can be used as a prediction factor for prostate cancer mortality. The IBF was found to be the best current predictor of prostate cancer mortality in patients previously treated with radiation therapy. Some background Biochemical failure is defined...
Read MorePostoperative radiotherapy prevents breast cancer recurrence and prolongs survival
In a nutshell This study evaluated if strategies to prevent cancer recurrence are associated with prolonged survival 15 years after treatment. Their main findings were that postoperative radiation managed to prevent cancer recurrence and was associated with higher rates of long-term survival. Some background Early breast cancer is often treated...
Read MoreWhat is the preferred mode of action for patients with Lobular Neoplasia: surgery or observation?
In a nutshell The present study tested whether Lobular Neoplasia (LN) diagnosed on Core Needle Biopsy (CNB) leads to breast cancer and if a selected group of patients can be safely observed rather than treated early. The main findings were that not all patients with LN diagnosed on CNB need surgery (excision). Some background Breasts are...
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