In a nutshell This study investigated if mild ovarian stimulation is as effective as conventional stimulation in vitro fertilization (IVF). They found that mild ovarian stimulation provides greater safety and lower cost, in addition to comparable success rates. Some background A part of the IVF process, women undergo a procedure to harvest...
Read MoreIn a nutshell This phase 4 trial aims to evaluate if co-administration of a gonadotrophin releasing-hormone (GnRH) agonist improves oocycte maturity. The main outcome to be investigated is the number of mature oocytes. The details One of the important steps during in vitro fertilization (IVF) is stimulating the maturation of oocytes (eggs). GnRH...
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In a nutshell This study investigated whether endometriosis surgery impacted pregnancy rates as a result of in vitro fertilization (IVF). They found that the severe endometriosis resulted in lower IVF pregnancy rates and the optimal time for IVF is 7-25 months following endometriosis surgery. Some background Endometriosis is a chronic condition...
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In a nutshell This study compared the effects of frozen embryo transfers against fresh embryo transfers in women undergoing in vitro fertilization (IVF). The frozen embryo transfers significantly reduced the risk of ectopic pregnancy. Some background Couples who are trying to get pregnant often turn to assisted reproduction methods such as IVF (a...
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In a nutshell This study examined whether bemfola has a similar safety and effectiveness profile as Gonal-f in women undergoing assisted reproductive technology. Some background Follicle-stimulating hormone (FSH) is a female hormone which is involved in the development of eggs in the ovaries. Gonal-f (follitropin alfa) is a drug which acts in...
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In a nutshell This study examined the accuracy of anti-Mullerian hormone in predicting pregnancy success. Some background Tests that identify women who require fertility treatment currently measure the ovarian reserve (number of eggs remaining in the ovary). Measures of ovarian reserve such as follicle-stimulating hormone (FSH) have low accuracy....
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In a nutshell This study examined the use of methotrexate or salpingectomy as a treatment for ectopic pregnancy, and explored whether these treatments affect the chances of subsequent successful in vitro fertilization cycles. Some background In-vitro fertilization (IVF) is when a male sperm fertilizes the females’ egg in a laboratory dish...
Read MoreIn a nutshell This study examined the rate of ectopic pregnancy after in vitro ferilization differed with the use of fresh or frozen-thawed eggs. Some background In-vitro fertilization (IVF) is when a male sperm fertilizes the females’ egg in a laboratory dish outside the body, and is implanted into the...
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In a nutshell This trial aims to evaluate the impact of Comprehensive Chromosome Screening (CCS) on patients with low ovarian reserve (the ovaries have a reduced capacity to provide eggs that are capable of fertilization), in an effort to improve success during in vitro fertilization (IVF) and decrease the time to successful pregnancy. The main outcome...
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In a nutshell This paper studied the effect of different amounts of recombinant human follicle stimulating hormone in patients undergoing assisted reproduction. Some background Ovarian stimulation is a technique where medications are used to stimulate the release of eggs in assisted reproduction. Recombinant human follicle-stimulating...
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In a nutshell This paper evaluates the effects of berberine compared to metformin in women with polycystic ovary syndrome who undergo IVF treatment. Some background Polycystic ovary syndrome causes infertility, an excess of androgen (male sex hormone) and anovulation (eggs not released from the...
Read MoreIn a nutshell This trial compared the long-term reproductive effects of two treatment strategies in women diagnosed with polycystic ovary syndrome (PCOS): laparoscopic ovarian drilling versus gonadotropin analogs. Some background If conservative treatments (such as weight loss) fail, women with PCOS may be treated with fertility drugs to induce...
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