In a nutshell This study compared the effectiveness and safety of immune checkpoint inhibitors (ICIs) between randomized and real-world studies in patients with advanced non-small cell lung cancer (NSCLC) or melanoma. The data showed that ICIs were similarly effective and safe in both randomized and real-world studies for these patients. Some background...
Read MoreTreatment(s) now being considered-Immunotherapy Posts on Medivizor
Evaluating the risk of lung inflammation associated with immunotherapy in advanced melanoma.
In a nutshell This study evaluated the risk of pneumonitis (inflammation of the lung tissue) associated with immune checkpoint inhibitors (ICIs) for the treatment of patients with advanced melanoma. The data showed that ICIs were associated with a higher risk of pneumonitis compared with conventional chemotherapy in patients with advanced melanoma. Some...
Read MoreInvestigating the side effect profiles of different PD-L1/PD-1 inhibitor-based combination therapies.
In a nutshell This study investigated the side effect profiles of different PD-1/PD-L1 inhibitor-based combination therapies. The data showed that PD-1/PD-L1 inhibitors in combination with chemotherapy were associated with a higher risk of treatment-related side effects than with targeted therapy or immunotherapy combinations. Some background...
Read MoreIs cancer treatment with immune checkpoint inhibitors associated with infection risk?
In a nutshell This study is aimed to evaluate the risk of infection for patients who are treated with immune checkpoint inhibitors (ICI) for solid tumors. The study concluded that in frail patients, ICI therapy alone is safer compared to chemotherapy (CT). Some background Immunotherapy is a type of cancer treatment that makes use of the immune...
Read MoreIs cancer treatment with immune checkpoint inhibitors associated with infection risk?
In a nutshell This study is aimed to evaluate the risk of infection for patients who are treated with immune checkpoint inhibitors (ICI) for solid tumors. The study concluded that in frail patients, ICI therapy alone is safer compared to chemotherapy (CT). Some background Immunotherapy is a type of cancer treatment that makes use of the immune...
Read MoreEvaluating the risk of heart-related side effects in patients treated with immune checkpoint inhibitors
In a nutshell This study evaluated the risk of heart-related (HR) side effects in patients with melanoma treated with immune checkpoint inhibitors (ICI). Patients with melanoma were shown to have a higher risk of developing HR side effects when treated with ICIs. Some background ICIs are a type of cancer therapy used to treat a wide variety...
Read MoreEvaluating immune-related side effets in patients with advanced melanoma treated with immunotherapies
In a nutshell The study monitored the occurrence of possible immune-related side effects (irSEs) in patients with advanced melanoma under single and combination therapy of ipilimumab (I; Yervoy), nivolumab (N; Opdivo), and pembrolizumab (P; Keytruda). The authors found that combination therapy increases the frequency of irSEs. Some background...
Read MoreWhat side effects of the skin can biological therapy cause?
In a nutshell This article reviewed the skin side effects caused by anti-PD-1 biological therapy. Some background Anti-PD-1 is a type of biological therapy that has significantly improved treatment results for patients with certain types of cancer. It works by blocking PD-1, a molecule that cancer cells use to switch off the immune...
Read MoreWhat gut-related side effects do immunotherapy drugs and chemotherapy cause patients with cancer?
In a nutshell This study examined if certain immunotherapy drugs increased the risk of developing side effects in the gut in patients with cancer also receiving chemotherapy. The results showed that immunotherapy drugs increased the risks of developing gut-related side effects compared to chemotherapy alone. Some background Immunotherapy drugs that...
Read MoreWhat gut-related side effects do immunotherapy drugs and chemotherapy cause patients with cancer?
In a nutshell This study examined if certain immunotherapy drugs increased the risk of developing side effects in the gut in patients with cancer also receiving chemotherapy. The results showed that immunotherapy drugs increased the risks of developing gut-related side effects compared to chemotherapy alone. Some background...
Read MoreWhat types of skin-related side effects do biological treatments cause in patients with melanoma?
In a nutshell This article reviewed the types and frequency of different skin-related side effects that patients with melanoma experience while receiving biological treatments. Some background Treatment for patients with melanoma has changed in recent years from chemotherapy to biological therapies. Biological therapies include BRAF inhibitors...
Read MoreReal-world safety and effectiveness of BRAF inhibitors and anti-CTLA4 antibody in melanoma
In a nutshell This article investigated the safety and effectiveness of BRAF inhibitors like vemurafenib (Zelboraf) and dabrafenib (Tafinlar) and immunotherapy such as ipilimumab (Yervoy) in a real-world setting for patients with advanced melanoma. The authors concluded that this therapy is safe and...
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