In a nutshell This study examined the effectiveness and safety of adding durvalumab (Imfinzi) to platinum-etoposide to treat patients with small-cell lung carcinoma (SCLC). The authors found that durvalumab was well-tolerated and improved survival outcomes. Some background Small cell lung carcinoma (SCLC) is a type of lung cancer that...
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In a nutshell This trial is examining the effectiveness of the antibody-drug conjugate SYD985 for HER2-positive inoperable advanced breast cancer. The main outcome to be measured will be time from treatment until disease progression or the time taken for tumor growth or spread. This study is being conducted in Baltimore, Maryland, inthe United...
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In a nutshell The authors reviewed the benefits and safety of ado–trastuzumab emtansine (Kadcyla), a treatment for metastatic breast cancer (cancer that has spread to other areas of the body). Some background Human epidermal growth factor receptor 2 positive (HER2) breast cancer depends on HER2 for growth. Treatments that target the HER2...
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In a nutshell The authors aimed to assess the effectiveness of traditional Chinese medicine used with conventional breast cancer treatments on breast cancer survival. Some background Traditional Chinese medicine is an alternative therapy that can complement breast cancer treatments. This generally includes various forms of herbal medicine,...
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In a nutshell The study investigated whether cetuximab (Erbitux) and brivanib alaniate (BMS-582664) can improve the quality of life of patients with chemotherapy-refractory metastatic colorectal cancer. Some background Some patients with colorectal cancer have chemotherapy-refractory metastatic cancer (the cancer does not respond to chemotherapy...
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In a nutshell This review analyzed the results from several clinical trials which compared the benefits of the standard dose of 250mg of fulvestrant (Ful) once a month to higher doses in breast cancer patients. Some background Some breast cancers need estrogen (a female sex hormone) to grow. Cancer cells respond to estrogen via...
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In a nutshell This phase III trial aims to determine the benefits of using the drugs eflornithine and sulindac (Clinoril) in the prevention of high risk adenomas and secondary colorectal cancers. Researchers will look at the number of recurrences over a 3 year period while administering the drugs. The details Patients previously treated for...
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In a nutshell This article presents the results of a phase III clinical trial that evaluated the safety and efficacy of Toremifene (Acapodene) for lowering fracture risk in men with prostate cancer receiving androgen deprivation therapy (ADT). The risk of spinal fractures was significantly reduced in patients who received Toremifene. Some background...
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In a nutshell This study looks at the use of panitumumab and irinotecan as a combination treatment in patients with KRAS wild-type (non-mutated) metastatic colorectal cancer which has continued to progress while on standard chemotherapy (oxaliplatin, fluoropyrimidines, irinotecan, bevacizumab). Some background Cancer cells can have...
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In a nutshell This study presents the results of a phase III clinical trial evaluating the efficacy and safety of the drug trametinib for the treatment of metastatic melanoma patients with BRAF mutations. Some background BRAF is a protein from a chain of proteins in the cell called the MAP kinase pathway. These play a role in cell division and...
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In a nutshell This paper presents results from phase I and II clinical trials evaluating the safety and efficacy of two targeted therapies – dabrafenib and trametinib – given in combination for metastatic melanoma patients with BRAF mutations. Some background BRAF is a protein that plays a role in cell division and growth. About 50% of...
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In a nutshell This paper summarizes the successful administration of the tumor targeting immunocytokines L19-IL2 and L19-TNF in combination with Ipilimumab (Yervoy) which resulted in the complete regression of the tumor in mice. Some background Metastatic melanoma is an aggressive form of skin cancer with limited treatment options due to...
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