In a nutshell This study evaluated the benefit of adding hyperthermic intraperitoneal chemotherapy (HIPEC) to cytoreductive surgery (CS) for the treatment of colorectal cancer (CRC) that has spread to the peritoneum (the lining of the abdomen that covers all abdominal organs). The study found that HIPEC added to CS did not improve the outcomes of...
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In a nutshell This study investigated the effects of exercise on recovery from colorectal cancer surgery. Researchers reported that exercise was associated with an improved recovery. Some background Recovery after surgery is only complete when the patient is able to return to normal day-to-day life. Not all colorectal cancer patients recover their...
Read MoreIn a nutshell This study investigated the safety of hyperthermic intraperitoneal chemotherapy (HIPEC) and surgery in colon cancer patients with peritoneal metastasis (PM). Researchers reported that HIPEC and surgery was associated with an increased risk of complications. Some background When colon cancer spreads to the abdominal lining (known as...
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In a nutshell This study examined the medium-term outcomes of single-incision laparoscopic surgery in the treatment of rectal cancer. Some background One major aspect of treatment for rectal cancer is surgery to remove the cancerous tissue. This is generally a major surgery which can be difficult to recover from. Newer techniques, such as...
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In a nutshell This study looked at whether a blood test which measures plasma osteopontin (OPN) levels can predict the likely course of colorectal cancer. Some background The pronosis of colorectal cancer (CRC) following surgery remains poor. This is often due to the cancer spreading. It is hoped that by finding a method of predicting or...
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In a nutshell This study looked at the impact of two treatments, chemoradiotherapy and chemotherapy, on the survival of patients with rectal cancer and on the return of their cancer. Some background Normally, prior to surgery to remove rectal cancer, a combination of chemotherapy and radiotherapy is given. Chemotherapy uses a drug or...
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In a nutshell This study compared two treatments for peritoneal metastasis in colorectal cancer (cancer that has spread to the lining of the abdomen). Some background Peritoneal metastasis is a serious complication of colorectal cancer. It is not usually treatable with standard chemotherapy, which is injected into veins or given by...
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In a nutshell This study examined whether skeletal muscle mass could be used to predict complications in colorectal cancer patients undergoing treatment for cancer that has spread to the peritoneum (the lining of the abdomen). Some background Metastatic colorectal cancer indicates that the cancer has spread from the colon or rectum to another...
Read MoreIn a nutshell This study compared the outcome of patients with colorectal or appendix cancer that had spread to the peritoneum (the lining of the abdominal cavity). Some background Peritoneal metastasis indicates that the initial cancer has spread to the peritoneum. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CS/HIPEC) is...
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In a nutshell This study examined the impact of smoking on the results of colorectal surgery. Some background Surgery for the removal of colorectal cancer, like any surgical intervention, carries the risk of serious complications. Smoking has been found to be a risk factor for complications in several types of major surgery. This is presumably due...
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In a nutshell The present clinical trial compared two chemotherapy regimens as first-line treatment for patients with metastatic colorectal cancer (mCRC): XELIRI-bevacizumav versus FOLFIRI-bevacizumab. Some background Approximately one quarter of patients with colorectal cancer (cancer in the large intestine) have metastases,...
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In a nutshell The present study compared the efficacy of two surgical techniques to treat pseudomyxoma peritonei (PMP): debulking and cytoreduction. Cytoreductive surgery achieved better surgical results and yielded higher 3- and 5-year survival rates, compared with debulking. Some background PMP is a rare condition caused by the production of...
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