In a nutshell This study investigated the safety and effectiveness of capecitabine (Xeloda) as treatment for advanced colorectal cancer in patients 75 or more years old. Researchers suggested that this drug was effective in patients aged 75 or older with colorectal cancer, with manageable side effects. Some background Chemotherapy has...
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In a nutshell This study compared the effectiveness of the combined treatment with chemotherapy and bevacizumab (Avastin) to chemotherapy alone in advanced colorectal cancer. Researchers suggested that the combination therapy improves the treatment of these patients. Some background Colorectal cancer is one of the most common cancers causing death...
Read MoreIn a nutshell This study reviews the value of TAS-102 in the treatment of colorectal cancer that has progressed with other therapies. Researchers suggested that TAS-102 is an important treatment option for patients with progressive colorectal cancer. Some background Colorectal cancer is the third most frequently diagnosed cancer in men and the...
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In a nutshell The aim of this phase 1 trial is to study the effectiveness of treatment with AZD1775 combined with the chemotherapy irinotecan (Camptosar). The main outcome to be measured is the tumor response to the treatment and toxicity. The details Chemotherapy is a standard treatment to colorectal cancer. It reduces symptoms and prolongs...
Read MoreIn a nutshell The aim of this trial is to determine the effectiveness of a combination of the chemotherapies docetaxel (Taxotere) and carboplatin (Paraplatin) in advanced (spread beyond the prostate) prostate cancer. The main outcome to be measured is the number of patients who experience a decrease of 50% in prostate specific...
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In a nutshell This study aimed to investigate whether neoadjuvant systemic therapy (NST) influenced the eligibility of HER2 positive breast cancer patients to undergo breast conserving therapy (BCT). This study concluded the use of NST can result in patients who are non-eligible for BCT converting to patients that are eligible for BCT. Some...
Read MoreIn a nutshell This study provided a long-term follow-up of patients diagnosed with early-stage Hodgkin lymphoma. The study concluded that current strategies for reduced intensity treatment of early-stage Hodgkin lymphoma are generally safe and effective. Some background Hodgkin lymphoma (HL) is generally considered a curable disease....
Read MoreIn a nutshell This study investigated the effects of surgery and post-surgery chemotherapy in elderly stage 3 colon cancer patients. Researchers reported that post-surgery chemotherapy improves long-term survival of these patients. Some background Surgery and post-surgery chemotherapy are the standard treatment for stage 3 colon cancer. Several...
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In a nutshell This study assessed the effectiveness of using escalated BEACOPP plus rituximab chemotherapy in patients with advanced stage Hodgkin Lymphoma. The study concluded that adding rituximab to the standard escalated BEACOPP regimen did not significantly improve time to disease progression. Some background Hodgkin Lymphoma (HL) is...
Read MoreIn a nutshell This study investigated the safety and effectiveness of treatment with combination cyclophosphamide (Cytoxan), methotrexate (Otrexup) and 5-fluoruoracil (Efudex) (CMF) plus trastuzumab (Herceptin) in HER2-positive metastatic breast cancer (MBC, cancer that has spread beyond the breast) patients. CMF plus trastuzumab (CMF+T) was found to...
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In a nutshell The aim of this study was to investigate if circulating tumor cells (CTC) levels in the blood could be used to determine the outcome for metastatic castration resistant prostate cancer patients. This study concluded that CTC levels could be used to predict survival in these patients. Some background Treatment for metastatic...
Read MoreIn a nutshell This study investigated the accuracy and reliability of sentinel lymph node biopsy (SNLB) before neoadjuvant systemic therapy (NAST) has begun in breast cancer patients. The study concluded that SLNB before NAST is highly reliable. The authors suggested that patients with a negative SLNB may be able to avoid lymph node removal and...
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