In a nutshell This study compared the effectiveness of the combined treatment with chemotherapy and bevacizumab (Avastin) to chemotherapy alone in advanced colorectal cancer. Researchers suggested that the combination therapy improves the treatment of these patients. Some background Colorectal cancer is one of the most common cancers causing death...
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In a nutshell This report summarized updates made to the guidelines for treatment of HER2-positive breast cancer with adjuvant chemotherapy and targeted therapy. Some background Adjuvant chemotherapy (treatment after surgery) is often used to prevent cancer recurrence. Chemotherapy involves agents that work to kill cancer cells in the body....
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In a nutshell This trial looked at the effectiveness and safety of an immunotherapy drug, atezolizumab (Tecentriq). The authors concluded that this drug is effective and safe to treat patients with advanced non-small-cell lung cancer who have high levels of the PD-L1 protein. Some background Immunotherapy is a fairly new type of cancer treatment....
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In a nutshell This phase 2 trial aims to test the effectiveness of a combined treatment with nivolumab (Opdivo) and brentuximab vedotin (Adcetris) in older patients with Hodgkin lymphoma. The main outcome to be measured will be the response of the tumor to the treatment. This trial is recruiting in California, Columbia, Illinois, Minnesota, Missouri,...
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In a nutshell This phase 2 trial aims to test the safety and effectiveness of a combined treatment with ibrutinib (Imbruvica) and brentuximab vedotin (Adcetris) in recurrent (when the cancer comes back) Hodgkin lymphoma patients or in those who did not respond to the first line of treatment. This trial is recruiting in California, United...
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In a nutshell This phase 2 trial aims to test the safety and effectiveness of treatment with irutinib (Imbruvica) and nivolumab (Opdivo) in patients with recurrent (when the cancer comes back) Hodgkin lymphoma or that has not responded to the first line treatment. The main outcome to be measure will be the response of the cancer to treatment. This...
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In a nutshell This study investigated the role of trastuzumab (Herceptin) as part of standard care in patients with human epidermal growth factor receptor-2 positive (HER2+) early breast cancer (BC). The study conclude that trastuzumab was effective in general practice, including patients not often included in clinical trials (such as the...
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In a nutshell This study investigated how the early development of a rash in treatment with lapatinib (Tykerb) impacts survival outcomes in breast cancer. This study concluded that early development of rash may indicate the patients who will benefit more from lapatinib. Some background Lapatinib is a drug which targets epidermal...
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In a nutshell This study investigated the effect of panitumumab (Vectibix) in overall survival of patients with metastatic colorectal cancer without a KRAS or RAS mutation. Researchers suggested that panitumumab significantly improved survival in these patients. Some background Panitumumab is a therapy that targets a...
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In a nutshell This study investigated the effectiveness and safety of the chemotherapy XELOX combined with cetuximab (Erbitux) as treatment for metastatic (spread to other parts of the body) colorectal cancer. Researchers suggested that this combination was effective in these patients with manageable side effects. Some background Colorectal...
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In a nutshell This study compared the effectiveness of the chemotherapy FOLFIRI plus cetuximab (Erbitux) and FOLFIRI plus bevacizumab (Avastin). Researchers suggested that FOLFIRI plus cetuximab is associated with a higher effectiveness in treating metastatic (spread to other parts of the body) colorectal cancers. Some background FOLFIRI is...
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In a nutshell This study compared the effectiveness of the chemotherapy mFOLFOX6 combined with tivozanib (Tivopath) or bevacizumab (Avastin) in metastatic colorectal cancer. Researchers suggested that these two treatments are equally effective. Some background Roughly 20% of colorectal cancer patients have metastasis (spread to other parts of...
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