In a nutshell The authors aimed to determine whether African Americans underwent more frequent reclassifications than Caucasians on active surveillance. Some background Active surveillance involves close observation of the cancer to detect any signs of cancer progression rather than immediate treatment. This is typically carried out in...
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In a nutshell The authors aimed to determine whether patients developed unfavorable disease features while under active surveillance. Some background Active surveillance involves no treatment. It involves close monitoring of prostate cancer patients to determine any sign of progression. It is currently recommended in low/intermediate risk...
Read MoreIn a nutshell This study compared the outcomes between the standard chemotherapy treatment for advanced non-small-cell lung cancer and a new drug, afatinib (Gilotrif, Giotrif) in Asian populations. Some background Non-small-cell lung cancer (NSCLC) is a common type of lung cancer but can be difficult to treat. Standard treatment involves...
Read MoreIn a nutshell This trial, recruiting in China only, aims to evaluate whether adding bevacizumab (Avastin) to radiation and chemotherapy regimens is a more effective treatment for locally advanced rectal cancer (cancer that has started to infiltrate surrounding tissues). The main outcome being investigated is tumor regression (shrinkage) following the...
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In a nutshell This paper studied the outcomes of a skin-sparing mastectomy procedure. Some background More and more people are undergoing skin-sparing mastectomies. This is a treatment for breast cancer where breast tissue is removed, but the overlying skin is preserved as much as possible. It also allows for immediate breast...
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In a nutshell This study investigated whether multiple biopsies can influence erectile function in low-risk prostate cancer patients. Some background Continuous monitoring of prostate cancer (active surveillance) is becoming an increasingly common management strategy for patients with low risk cancer. It involves regularly repeating...
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In a nutshell This phase 2 trial compared the efficacy of panitumumab and modified chemotherapy regimen (mFOLFOX6) compared to bevacizumab and mFOLFOX6 in patients with unresectable, metastatic colorectal cancer. Some background Unresectable metastatic colorectal cancer (mCRC) is cancer that has spread from the...
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In a nutshell This study investigated the effectiveness of a single session of high-intensity focused ultrasound (HIFU) in patients with localized (confined) prostate cancer, as a potential curative treatment. Some background Radiotherapy or RT (the use of high-energy rays to kill cancer cells) is a widely used, non-invasive therapy for...
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This article discussed current scientific data concerning the need and benefit of surgical treatment for endometriomas before in-vitro fertilization (IVF). Endometriosis is a condition in which the tissue that lines the innermost layer of the uterus is found elsewhere in the body. Frequently, this tissue is found in the ovaries, where it may lead...
Read MoreIn a nutshell This trial compares two treatment protocols for couples without a known cause for infertility: a conventional and an accelerated regimen. Some background Fertility treatments and procedures are usually given in a step-wise fashion. For most couples with trouble conceiving, the first fertility treatment given...
Read MoreIn a nutshell This article reviewed current data regarding pregnancy outcomes in women with endometriosis treated with a gonadotropin-releasing hormone (GnRH) analog before in-vitro fertilization (IVF). Some background Endometriosis is a condition in which cells of the inner-most layer of the uterus can be found in other organs (most commonly the...
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In a nutshell This study examined which intrauterine insemination (IUI) protocol yields the best pregnancy outcomes in women in which ovulation was induced using medications. Some background The first line of treatment in many infertile couples is the combination of ovulation induction drugs plus IUI. Induced ovulation involves giving medications,...
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