In a nutshell This study compared the safety and effectiveness of two first-line chemotherapy regimens for diffuse large B-cell lymphoma. This study concluded that the R-THP-COP regimen was as effective as conventional R-CHOP for diffuse large B-cell lymphoma. Some background R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine,...
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In a nutshell This study compared the safety and effectiveness of two first-line chemotherapy regimens for diffuse large B-cell lymphoma. This study concluded that the R-THP-COP regimen was as effective as conventional R-CHOP for diffuse large B-cell lymphoma. Some background R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine,...
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In a nutshell This study analyzed different types of induction chemotherapy regimes in secondary acute myeloid leukemia. The authors concluded that the FLAG combination had a high response rate and a low level of treatment-related side effects. Some background Secondary acute myeloid leukemia is a type of leukemia arising from a pre-existing...
Read MoreIn a nutshell This study investigated the safety and effectiveness of obinutuzumab (Gazyva) versus rituximab (Rituxan) plus chemotherapy for previously untreated follicular lymphoma. This study concluded that obinutuzumab improved survival outcomes compared to rituximab. Some background Follicular lymphoma is the most common type of...
Read MoreIn a nutshell This study aimed to investigate the effectiveness and safety of a lower dose of dasatinib in chronic phase chronic myeloid leukemia patients. This study concluded that the lower dose of dasatinib was as effective and safer than the standard dose in these patients. Some background Dasatinib (Sprycel) is a tyrosine kinase inhibitor...
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In a nutshell This study aimed to find out if radiation added to standard chemotherapy could increase the response to treatment for locally advanced breast cancer. This study found that neoadjuvant radiation added to chemotherapy improved response but not overall survival. Some background Chemotherapy is a treatment option for...
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In a nutshell This study investigated the outcomes of advanced-stage classical Hodgkin’s lymphoma (HL) patients treated with ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) chemotherapy followed by escalated (higher dose) BEACOPP (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone) chemotherapy...
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In a nutshell This phase 2 clinical trial will test the safety and effectiveness of blinatumomab (Blincyto) after an R-chemotherapy in treating newly diagnosed patients with diffuse large B-cell lymphoma (DLBCL). The primary outcome will be measured by adverse (negative) side effects. The details Blinatumomab is an immunotherapy that uses the...
Read MoreIn a nutshell This phase 3 clinical trial will test the effectiveness of blinatumomab (Blincyto) with chemotherapy versus chemotherapy alone in treating patients with newly diagnosed B lineage acute lymphoblastic leukemia (ALL) that is BCR-ABL negative. The primary outcome will be measured by the overall survival. The details Blinatumomab is...
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In a nutshell This phase 2 clinical trial will test the effectiveness of a combination treatment, consisting of ibrutinib (Imbruvica), fludarabine (Fludara), cyclophosphamide (Cytoxan), and obinutuzumab (Gazyva), in treating chronic lymphocytic leukemia (CLL). The primary outcome will be measured by the response to treatment. This trial is being...
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In a nutshell This study analyzed the results of multiple studies to examine the effect of bortezomib (Velcade) on cardiac risk (heart health) in multiple myeloma. Results showed no effect on cardiac risk with bortezomib-based treatment. The incidence of cardiac events was low across all treatment groups. Some background Many multiple myeloma...
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In a nutshell This study investigated the impact of whole breast radiation therapy (WBRT) and accelerated partial breast irradiation (APBI) on the severity of post-treatment side effects and quality of life. This study concluded that both forms of radiation therapy (RT) show similar survival benefits and similar quality of life in early-stage breast...
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