In a nutshell This study examined if vascular-targeted photodynamic therapy (VTPT), or active surveillance is more effective in the treatment of low-risk prostate cancer. This study concluded that patients who received VTPT were less likely to require radical therapy compared to those who underwent active surveillance. Some background...
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In a nutshell This phase 2 trial will investigate the safety of durvalumab (Imfinzi) in combination with standard hormonal treatment for breast cancer (BC). The main outcome will be the response to treatment. The trial is recruiting in Tampa, Florida, US. The details Breast cancer (BC) is one of the most common cancers. It affects bothe...
Read MoreIn a nutshell This trial is examining a new anti-cancer medication for non-small cell lung cancer called tislelizumab. The main outcome that will be measured is how long it takes for the cancer to start growing again. This study is recruiting across the United States. The details Non-small cell lung cancer (NSCLC) can be...
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In a nutshell This study determined whether osimertinib (Tagrisso) was more effective than erlotinib (Tarceva) in patients with non-small cell lung cancer (NSCLC) with the EGFR mutation. The study found that treatment with osimertinib improved survival compared to standard-care treatment for these patients. Some background...
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In a nutshell This phase 2 trial is evaluating the effectiveness of acalabrutinib (Calquence) with or without obinutuzumab (Gazyva) for small lymphocytic lymphoma (SLL). The main outcome to be measured will be the number of patients who have a complete disappearance of all signs of cancer. This study is being conducted in Phoenix, Arizona, Jacksonville,...
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In a nutshell This study evaluated the long-term effectiveness and safety of a new chemotherapy regimen in patients with previously untreated indolent (painless) non-Hodgkin’s lymphoma (NHL). This study concluded that this regimen is effective and well-tolerated for these patients. Some background There are three common types of painless NHL....
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In a nutshell This trial is examining the safety and effectiveness of pembrolizumab (Keytruda) in the treatment of children and young adults with classical Hodgkin lymphoma (HL). The main outcome to be measured will be a response to treatment. This trial is recruiting in the Republic of Korea and the United States. The details...
Read MoreIn a nutshell This trial is investigating the effects of AVD [doxorubicin (Adriamycin), vinblastine (Velban), and dacarbazine (DTIC)] with brentuximab vedotin (Adcetris) induction chemotherapy, plus nivolumab (Opdivo) for Hodgkin lymphoma (HL). The main outcome to be measured is survival without cancer worsening 3 years after treatment. The details...
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In a nutshell This phase 2 trial will investigate the safety and effectiveness of a prostate cancer vaccine. The main outcome will be the rate of prostate cancer progression. The details Prostate cancer (PC) is cancer the originates in the prostate gland (PG). PC is very common, however, most men will recover from it. The progression of PC is...
Read MoreIn a nutshell This Phase 3 study is evaluating the safety and effectiveness of midostaurin (Rydapt) combined with chemotherapy for patients with newly-diagnosed acute myeloid leukemia (AML). The main outcome to be measured will be event-free survival at 5 years. The details Previous studies have shown that midostaurin combined with chemotherapy is...
Read MoreIn a nutshell This study is comparing the effectiveness of R-CHOP chemotherapy with or without enzastaurin (Kinenza) in patients with previously untreated diffuse large B-cell lymphoma (DLBCL). The main outcome to be measured will be overall survival at the end of the study. The details The current standard first-line treatment for DLBCL is R-CHOP...
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In a nutshell This trial evaluates the effectiveness of radiation therapy delivered from outside the body for the treatment of prostate cancer. The main outcomes of this trial are the number of patients who have no damage to genital or urinary organs and survival without cancer. This trial is taking place in various sites across the USA and...
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