In a nutshell This study evaluated the role of circulating tumor cells (CTCs) in deciding adjuvant therapy (AT; treatment after surgery) in patients with breast cancer (BC). This study showed that personalized AT based on CTCs improved patient survival. Some background BC that has not spread to other areas of the body is called non-metastatic...
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In a nutshell This article was carried out to look at how histological grade (HG) impacts the outcomes of older women with early-stage (ES) breast cancer (BC) treated with breast-conserving therapy (BCS) with or without radiotherapy (RT). The authors found that the treatment of ESBC without RT resulted in a lower cancer-specific survival...
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In a nutshell This study aimed to investigate the outcomes of accelerated partial breast irradiation (ABPI) with TomoTherapy (TT) after breast conservative surgery (BCS) in patients with invasive breast cancer. This study concluded that this treatment is safe and effective with good long-term outcomes in these patients. Some...
Read MoreIn a nutshell This trial aims to find out what dose of radiation therapy is effective in the shortest time period for women with newly diagnosed breast cancer, or ductal carcinoma in-situ (DCIS). The main outcome that will be measured is if patients experience any side effects. The study is taking place in New Jersey and New York, the United States. The...
Read MoreIn a nutshell This study aimed to investigate the outcomes of standard adjuvant chemotherapy versus capecitabine (Xeloda) in older patients with breast cancer after 10 years. This study concluded that with longer follow up, outcomes remained superior with standard adjuvant chemotherapy. Some...
Read MoreIn a nutshell This study investigated if trastuzumab (Herceptin)/paclitaxel (Taxol) reduces the risk of local-regional recurrence (LRR) in patients with HER2-positive breast cancer (BC). They found that this treatment reduced LRR risk in HER2-positive patients. Some background Breast cancer (BC) is one of the most common cancers....
Read MoreIn a nutshell This study wanted to find out if adding the medication denosumab (Prolia, Xgeva) to cancer treatment for women with breast cancer reduces the risk of bone fractures. The study found that the patients treated with denosumab survived better, but there was no significant difference in the number of bone fractures. Some background Breast...
Read MoreIn a nutshell This trial aims to find out if targeted radiotherapy on the breast in women with low-risk breast cancer after breast-conserving surgery will prevent the cancer from coming back. The main outcome that will be measured is how long it takes before the breast cancer comes back. The study is being conducted in Canada and the United States. The...
Read MoreIn a nutshell This article investigated the safety and effectiveness of myofascial release (MR) therapy on women survivors of breast cancer. The authors concluded that MR therapy is safe and resulted in physical benefits (overall shoulder movement, functionality, pain). Some background Surgery and radiation are among the main treatments for...
Read MoreIn a nutshell This is a 2018 update on breast reconstruction following breast cancer treatment. It has been found that nearly 40% of women who undergo a mastectomy will have a breast reconstruction. Some background It was estimated that in 2017 106000 reconstructive breast surgeries were done. The main reason for this is to do with the psychological...
Read MoreIn a nutshell This trial aimed to evaluate the use of a second treatment targeting HER-2 in a group of patients that had HER-2, HR positive metastatic breast cancer. This study found that patients treated with dual HER-2 medications with hormone therapy had a superior progression free survival as compared to those using one medication...
Read MoreIn a nutshell This phase 3 trial aims to evaluate how effective pembrolizumab (Keytruda) is at treating triple negative breast cancer. The main outcome to be investigated is the invasive disease free survival. Other outcomes include the overall survival (time from treatment until death from any cause) and side effects. This trial is taking place...
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