In a nutshell This study observed the safety and effectiveness of the drug Gemtuzumab Ozagamicin (Mylotarg) when given to children with acute myeloid leukemia unresponsive to treatment. The authors found the treatment to be effective in children who became unresponsive to bone marrow transplant therapy. Some background Acute Myeloid...
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In a nutshell This study observed the effects of a protein treatment called interferon-alpha in patients with acute leukemia unresponsive to transplant therapy. The authors found that this treatment was effective in improving treatment response and survival in these patients. Some background Interferon-alpha (IFN-a) is a type of...
Read MoreIn a nutshell This study investigated the safety and effectiveness of rituximab (Rituxan) plus bortezomib (Velcade) for patients with mantle cell lymphoma after stem cell transplant. This study concluded that this combination is a safe and effective regimen in these patients. Some background The standard treatment for younger patients with mantle cell...
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In a nutshell This study aimed to identify the outcomes and prognostic factors following a stem cell transplant from a donor in adults with acute myeloid leukemia in their second complete remission (no sign of disease). The authors determined that this type of transplant was effective in these patients. Some background In adult patients with acute...
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In a nutshell This study looked at the effect of neutrophil recovery time (NRT – the return of white blood cells after treatment, that fight infection) on infections and relapse (return of disease) in children with acute myeloid leukaemia (AML). The study found that longer NRT was linked with increased risk of severe infections and relapse after...
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In a nutshell This study looked at the effect of neutrophil recovery time (NRT – the return of white blood cells after treatment, that fight infection) on infections and relapse (return of disease) in children with acute myeloid leukaemia (AML). The study found that longer NRT was linked with increased risk of severe infections and relapse after...
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In a nutshell This study investigated the safety and effectiveness of ibrutinib (Imbruvica) plus venetoclax (Venclexta) for the treatment of mantle cell lymphoma. This study concluded that this regimen improved outcomes in patients with mantle cell lymphoma. Some background The standard treatment for mantle cell lymphoma (MCL)...
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In a nutshell This study investigated the safety and effectiveness of alloHCT (allogeneic hematopoietic stem cell transplantation) in patients with chronic lymphocytic leukemia (CLL) pre-treated with ibrutinib (Imbruvica). This study concluded that ibrutinib does not affect the safety of alloHCT. Some background Ibrutinib has become the standard of...
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In a nutshell This study aimed to investigate the use of stem cell transplant with a chemotherapy treatment regime in patients with acute myeloid leukemia. This study concluded that this regime is safe and effective in patients that receive stem cell transplants from a haploidentical (half or partially matched) donor. Some background The use of...
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In a nutshell This study aimed to investigate risk factors that influence the outcome of acute leukemia patients who experience relapse after hematopoietic stem cell transplant. This study concluded that certain factors, such as older age and not acheiving remission after relapse treatment, are associated with worse survival outcomes. Some...
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In a nutshell This study investigated the safety and effectiveness of ibrutinib (Imbruvica), lenalidomide (Revlimid), and rituximab (Rituxan) given together to patients with relapsed or refractory (not responding to treatment) mantle cell lymphoma (MCL). The authors conclude that this combination is effective in these patients, but not better than the...
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In a nutshell This study aimed to investigate the prevalence of metabolic syndrome in adult survivors of childhood acute leukemia. This study also aimed to determine the effect of different therapies on the occurrence of metabolic syndrome in these patients. This study concluded that metabolic syndrome is frequent among childhood AL survivors, regardless...
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