In a nutshell This study evaluated the effectiveness and safety of adding ixazomib (Ninlaro) to lenalidomide (Revlimid) maintenance therapy after autologous stem cell transplant (ASCT) in patients with newly diagnosed multiple myeloma (MM). The data showed that the addition of ixazomib to lenalidomide maintenance improved survival without cancer...
Read MoreTreatment(s) already received-Bone marrow transplant-Autologous Posts on Medivizor
Is lenalidomide a good choice as maintenance treatment in multiple myeloma?
In a nutshell This study examined whether multiple myeloma (MM) can become resistant to lenalidomide (Revlimid) when this drug is used as maintenance therapy (MT) after bone marrow transplant. The authors found that using lenalidomide when the cancer came back after lenalidomide MT was not associated with resistance and improved...
Read MoreSearching for patients to try a new treatment for multiple myeloma.
In a nutshell This study will investigate the effects of a new treatment, GSK2857916, in patients with multiple myeloma (MM). Overall response will be the main outcome measured. The details There are many treatment options for MM. However, some patients do not respond to treatments or relapse. New therapies are being developed for these patients....
Read MoreBortezomib plus lenalidomide for patients with multiple myeloma a after stem cell transplant
In a nutshell This study evaluated the safety and effectiveness of bortezomib (Velcade) and lenalidomide (Revlimid) for patients with multiple myeloma after stem cell transplantation. This study found this combination is effective for these patients, with few side effects. Some background Multiple myeloma (MM) is a type of cancer...
Read MoreIs stem cell transplant more effective than other treatments for multiple myeloma?
In a nutshell This study compared the effects of stem cell transplant to other newer treatments for recently diagnosed multiple myeloma (MM). The main finding was patients who received stem cell transplant had better outcomes than those who did not. Some background Stem cell transplant involves the transfer of cells to a patient. This is an effective...
Read MoreMinimal residual disease and its association with transplant success in Multiple Myeloma.
In a nutshell This study monitored the development of minimal residual disease (MRD) after transplant for multiple myeloma (MM). The main finding was that different patterns of MRD development are associated with varying success after stem cell transplant for MM. Some background There are many treatments for MM. Patients are often cured fully by...
Read MoreEvaluating the risk of developing acute myeloid leukemia or myelodysplastic syndrome after a stem cell transplant
In a nutshell This study evaluated the risk of acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) development in patients with lymphoma and myeloma after an autologous stem cell transplant (autoSCT). This study concluded that this risk is quite high after autoSCT in these patients. Some background AML and MDS are known long-term...
Read MoreOutcomes from early relapse in multiple myeloma
In a nutshell This paper studied the effect of early relapse on survival in patients with multiple myeloma. Patients who had an early relapse had a worse overall survival than patients who did not have an early relapse. Some background Despite advances in treatment, many patients with multiple myeloma will experience a relapse (have a return...
Read More