In a nutshell This study aimed to evaluate the long-term effectiveness and safety of high-dose chemotherapy (HDC) for the treatment of patients with unfavorable Hodgkin lymphoma (HL). The authors concluded that HDC increased the control of the disease in the long-term. Some background HDC with radiotherapy is a standard treatment of HL. 4 cycles of...
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In a nutshell This study aimed to compare the effects of oral hyaluronic acid (HA) and injections of HA into the scar tissues plaque, against the effects of injections alone in Peyronie's disease (PD). The results suggest that the combination treatment was more effective than injections alone. Some background PD is a noncancerous condition...
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In a nutshell The authors examined the relationship between prostate size and surgical outcomes following bipolar transurethral enucleation of the prostate (B-TUEP). The authors found that B-TUEP provided symptom relief regardless of prostate size in men with benign prostatic hyperplasia (BPH). Some background BPH is the non-cancerous...
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In a nutshell This study looked at the effectiveness selpercatinib (Retevmo) for the treatment of patients with RET fusion-positive non-small cell lung cancer (NSCLC) that has spread to the brain. The authors found that selpercatinib was effective in these patients. Some background RET mutations are genetic abnormalities that can cause some...
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In a nutshell This study looked at patients on triple therapy for blood pressure control. It found that taking fewer separate pills was associated with better blood pressure control. Some background Blood pressure (BP) can be difficult to manage in some patients. There are three main types of treatment that act on the body in...
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In a nutshell This study evaluated the short- and long-term outcomes of laparoscopic surgery (LS; keyhole surgery) for the treatment of elderly patients with colorectal cancer (CRC) aged over 80 years. The data showed that LS is a good and safe option for these patients. Some background Colorectal cancer (CRC) is one of the most common types of cancer...
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In a nutshell This study was carried out to assess the use of aromatase inhibitors (AI) versus tamoxifen (Novaldex) for women before menopause with estrogen receptor-positive (ER+) breast cancer (BC). The authors found that AIs were associated with better outcomes than tamoxifen in these patients. Some background About 80% of all BCs...
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In a nutshell The study aimed to compare the effectiveness of surgery versus radiation therapy for patients with high-grade localized prostate cancer (PCa). The study concluded that surgery was associated with improved survival compared to radiation therapy in these patients. Some background Prostate cancer (PCa) is the second most common...
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In a nutshell This study investigated whether switching a first-line targeted therapy (TT) within 6 months of not attaining low disease activity (LDA) enhances the chance of patients with rheumatoid arthritis (RA) achieving their target at the 12-month visit. The data showed an increased chance of achieving a target of remission or LDA at the...
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In a nutshell This study explored the effects of different second-line therapies combined with metformin (Glucophage) in patients with type 2 diabetes (T2D). The data showed that metformin combinations with a sulfonylurea (SU) had the lowest weight loss, the smallest effect of lowering blood glucose, and an overall, reduced health...
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In a nutshell This study aimed to compare outcomes of donor types for a second allogeneic stem cell transplant (alloSCT) in patients with relapsed acute lymphoblastic leukemia (ALL). This study concluded that there is no major difference in overall survival between a matched unrelated donor (MUD) and a half-matched donor (HMD) in...
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In a nutshell The study aimed to investigate the health-related quality of life (HR-QoL) for patients with chronic lymphocytic leukemia (CLL) who were treated with venetoclax (VEN; Venclexta) and obinutuzumab (Obi; Gazyva). This study concluded that this treatment is effective and does not impair the quality of life in these...
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