In a nutshell This study investigated the effectiveness and safety outcomes of nimotuzumab (Theraloc) combined with chemoradiotherapy (CRT) for the treatment of patients with locally advanced squamous non-small cell lung cancer (SqNSCLC). The data showed that nimotuzumab plus CRT had similar survival outcomes compared to CRT alone, but with a lower...
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In a nutshell This study evaluated the survival outcomes after lumpectomy followed by radiation versus mastectomy alone in patients with early-stage HER2-positive (HER2+) breast cancer (BC) and triple-negative breast cancer (TNBC) with low or high tumor-infiltrating lymphocytes (TILs). The data showed that lumpectomy followed by radiation improves...
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In a nutshell This study evaluated the effectiveness of CPX-351 (Vyxeos; daunorubicin, cytarabine) versus standard chemotherapy for older patients with high-risk acute myeloid leukemia (AML). This study found that CPX-351 improved long-term outcomes for these patients. Some background AML is a cancer of the blood and bone marrow. AML can also...
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In a nutshell This study looked at the use of surgery for spread disease (metastases) in patients with advanced melanoma when other whole-body treatments had failed. It found that surgical removal of metastases improved the outcomes of these patients. Some background Advanced melanoma can spread to many places in the body. It is usually...
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In a nutshell This study looked at continuous subcutaneous insulin infusions (CSII) for the treatment of diabetic retinopathy (DR; eye disease). It found that compared to multiple daily injections of insulin (MDI), CSII resulted in a less worsening of DR. Some background Diabetic eye disease, also called diabetic retinopathy (DR), is a...
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In a nutshell This study looked at the effectiveness of onabotulinumtoxinA (OBTA; Botox) injections for the treatment of overactive bladder (OAB) according to sex. It found that OBTA improved symptoms of OAB in women and men with lower levels of PSA (a protein made by the prostate that increases when the prostate is enlarged),...
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In a nutshell This study looked at the risk of urogenital infections in patients with diabetes taking sodium-glucose co-transporter 2 (SGLT2) inhibitors. It found that SGLT2 inhibitors increase the risk of urogenital infections in women over 50 years of age, especially in the first month of treatment. Some background SGLT 2 inhibitors such...
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In a nutshell This study looked at the use of levodopa-carbidopa intestinal gel (LCIG; Duodopa) for the treatment of severe dyskinesia in patients with advanced Parkinson's disease (PD). It found that LCIG improved symptoms in most patients but that dose adjustments were needed throughout treatment. Some background Parkinson's...
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In a nutshell This study reported the safety and effectiveness of a combination of carfilzomib (Kyprolis), bendamustine (Treanda), and dexamethasone (Decadron) for patients with relapsed or refractory (r/r) multiple myeloma (MM). The data showed that a combination of carfilzomib, bendamustine, and dexamethasone (CBd) showed promising...
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In a nutshell This study analyzed the effectiveness and safety of new hormonal therapies (nHTs) in patients with non-metastatic castration-resistant prostate cancer (CRPC). The authors concluded that nHT improved the outcomes of these patients. Some background CRPC is an aggressive type of prostate cancer that is resistant to androgen...
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In a nutshell This study looked at the combination of brentuximab vedotin (BV; Adcetris) and ICE salvage chemotherapy with ifosfamide (Ifex), carboplatin (Paraplatin), and etoposide (Etopophos) for the treatment of relapsing or refractory Hodgkin lymphoma (HL). This study showed that BV-ICE was a good salvage treatment option for...
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In a nutshell This study looked at tirzepatide, a new treatment for type 2 diabetes, compared to semaglutide (Ozempic). It found that, depending on the dose, tirzepatide was similarly or more effective at controlling blood glucose than semaglutide. Some background Tirzepatide is a new type of medication designed to treat type 2...
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