In a nutshell This trial compared intracytoplasmic sperm injection (ICSI) to conventional in vitro fertilization (IVF) for couples where men have normal sperm quality. It found there was no clear benefit to ICSI over IVF for these couples. Some background IVF is an infertility treatment in which the woman’s ovaries are stimulated to produce...
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In a nutshell This study looked at the safety and effectiveness of olokizumab (Artlegia) as an add-on to methotrexate (Otrexup) treatment in rheumatoid arthritis. It found the olokizumab was associated with significant improvements in RA symptoms and physical function. Some background Rheumatoid arthritis (RA) is a condition affecting...
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In a nutshell This study looked at the effectiveness of deep brain stimulation (DBS) in patients with Parkinson's disease (PD) and stomach problems. It found that DBS was associated with an improvement in stomach disorders and a reduced need for medication. Some background PD is a neurologic condition that can be difficult to treat as...
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In a nutshell This study looked at the use of aflibercept (Eylea) eye injections for the treatment of severe nonproliferative diabetic retinopathy (DR; diabetic eye disease). It found that more than half of the patients treated with aflibercept showed a significant improvement in DR after 6 months. Some background DR is one of...
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In a nutshell This study compared the effect of administering 1.5 mg, 3 mg, and 4.5 mg of dulaglutide (Trulicity) on overall bodyweight reduction in patients with type 2 diabetes (T2D). The authors concluded that higher doses of dulaglutide caused more weight loss in these patients. Some background Abnormal or excessive levels of fat in the...
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In a nutshell This study assessed the effectiveness of Fluxonorm® herbal supplement when combined with standard therapy for lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH). The authors concluded that the effectiveness of standard therapy was improved by the addition of Fluxonorm® in patients with...
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In a nutshell This study compared 2 approaches of robot-assisted radical prostatectomy (RARP) for the treatment of localized prostate cancer (PCa). The authors concluded that both transvesical (T) and posterior (P) approaches had similar results in these patients. Some background Localized prostate cancer (PCa) is cancer that is...
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In a nutshell This study compared the effectiveness and safety of tofacitinib (Xeljanz) and baricitinib (Olumiant) in patients with rheumatoid arthritis in a real-world setting. The data showed that tofacitinib and baricitinib had similar effectiveness and safety but clinical responses may depend on previous use of anti-rheumatic drugs. Some...
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In a nutshell This study evaluated the effectiveness and safety outcomes of pembrolizumab (Keytruda) plus GVD (gemcitabine, vinorelbine, and liposomal doxorubicin) as second-line therapy for patients with relapsed or refractory (r/r) classical Hodgkin lymphoma (cHL). The data showed that the pembrolizumab plus GVD combination is safe and highly effective...
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In a nutshell This study investigated the long-term safety and effectiveness of tandem chimeric antigen receptor (tCAR) T-cell therapy for patients with relapsed or refractory (r/r) non-Hodgkin lymphoma (NHL). The data showed that tCAR T-cell therapy resulted in long-term remission rates with manageable side effects for these patients. Some...
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In a nutshell This study evaluated the role of 18F-fluciclovine-PET-CT versus conventional imaging (bone scan and either CT or MRI) alone for salvage radiotherapy (RT) after prostate surgery for the treatment of patients with localized prostate cancer (PCa). The data showed that including 18F-fluciclovine-PET-CT into the decision-making process for RT...
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In a nutshell This study evaluated the effectiveness and safety of adding isatuximab (Sarclisa) to carfilzomib (Kyprolis) and dexamethasone (Decadron) combination (Kd) for patients with previously treated relapsed multiple myeloma (MM). The data showed that adding isatuximab to the Kd regimen reduced the risk of disease progression or death for these...
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