In a nutshell This study assessed the effectiveness and safety of different long-acting and short-acting insulins for the treatment of patients with diabetes. The data supported the use of long-acting insulins instead of neutral protamine Hagedorn (NPH) insulin (Humulin N; Novolin N), as basal insulin for patients with type 2 diabetes (T2D). Some...
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In a nutshell This study compared the effectiveness and safety of extended therapy with letrozole (LET; Femara) for 5 years versus the standard therapy of 2-3 years for the treatment of postmenopausal women with early-stage breast cancer (BC). The data showed that extended treatment with LET for 5 years significantly improved the survival outcomes...
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In a nutshell This study investigated the effectiveness and safety of capecitabine (Xeloda) as maintenance therapy versus active monitoring for the treatment of patients with stable metastatic colorectal cancer (mCRC). The data showed that capecitabine maintenance improved survival without cancer worsening with manageable side effects for these...
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In a nutshell This study evaluated the long-term outcomes of stereotactic ablative radiation therapy (SABR) and video-assisted thoracic surgery (VATS) for the treatment of patients with early-stage non-small cell lung cancer (NSCLC). The data showed that both SABR and VATS led to similar long-term survival outcomes. Some background...
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In a nutshell This study evaluated the long-term functional and oncological outcomes of robotic-assisted laparoscopic radical prostatectomy (RALP) and open retropubic radical prostatectomy (RRP) for the treatment of patients with localized prostate cancer (PCa). This study found that RALP was associated with better oncological outcomes compared to...
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In a nutshell This study evaluated the effectiveness and safety of trastuzumab deruxtecan (Enhertu) in patients with previously untreated metastatic HER2-mutant non-small-cell lung cancer (NSCLC). The data showed that trastuzumab deruxtecan was safe and showed strong anticancer activity in these patients. Some background NSCLC is the most common form...
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In a nutshell This study reviewed the surgical management of benign prostatic hyperplasia (BPH). Some background Benign prostatic hyperplasia (BPH) is a condition in which the prostate grows larger than normal. The prostate can then squeeze the urethra (the tube that drains the bladder) causing problems with urination. Medical...
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In a nutshell The study aimed to investigate the safety and effectiveness of immunotherapy drug tebentafusp in previously untreated advanced uveal melanoma. The study showed that tebentafusp is effective and improved the overall survival in patients with uveal melanoma. Some background Melanoma is an aggressive kind of skin cancer. Uveal melanoma...
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In a nutshell This study compared the effectiveness and safety outcomes of nivolumab (N; Opdivo) plus ipilimumab (I; Yervoy) with chemotherapy versus pembrolizumab (Pem; Keytruda) plus chemotherapy as first-line treatment in patients with metastatic non-small cell lung cancer (NSCLC). The data showed that N-I plus chemotherapy provided similar overall...
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In a nutshell This study evaluated the long-term effectiveness and complication rates of the Altis® sling (Coloplast) use in women with predominant stress urinary incontinence (SUI). The data showed favorable results for long-term safety and effectiveness, and improved quality of life (QoL) in these patients. Some background SUI is a common...
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In a nutshell This review looked at SGLT2 inhibitor medications for people with both type 2 diabetes (T2D) and chronic kidney disease (CKD). It found that SGLT2 inhibitors reduced worsening of the kidneys for these patients. Some background For people with diabetes, the body cannot control the amount of glucose (sugar) in the blood without treatment....
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In a nutshell This study looked at pomalidomide (Pomalyst) for patients with multiple myeloma (MM) which had returned after previous treatment. It found that adding pomalidomide to Vd (bortezomib, dexamethasone) led to better outcomes than Vd alone. Some background MM is a blood cancer in adults. Myeloma cells are cancerous versions of plasma cells,...
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