In a nutshell This study evaluated the cardiovascular (CV; heart and blood vessels) side effects in patients with chronic lymphocytic leukemia (CLL) who received acalabrutinib (Calquence) treatment. The data showed that the occurrence of CV side effects with acalabrutinib treatment is very low in patients with CLL. Some background CLL is a type of...
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In a nutshell This study evaluated the effectiveness and safety of apalutamide (Erleada) in combination with abiraterone acetate (Zytiga) plus prednisone (Deltasone) (AAP) for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC). The data showed that apalutamide plus AAP combination significantly improved...
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In a nutshell This review aimed to explore the effectiveness and safety of gemtuzumab ozogamicin (GO; Mylotarg) in different subtypes of acute myeloid leukemia (AML). This review concluded that this treatment is safe and effective in certain patients with AML. Some background GO is an...
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In a nutshell The authors compared the safety and effectiveness of 90Y-antiCD25 (yttrium 90 basiliximab; aTac) radioimmunotherapy (RAI), followed by BEAM (carmustine, etoposide, cytarabine, melphalan) and autologous stem cell transplantation (ASCT) for the treatment of patients with high-risk relapsed or refractory (r/r) classical Hodgkin...
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In a nutshell This study compared the effectiveness and safety of tirzepatide to insulin degludec (Tresiba) in patients with uncontrolled type 2 diabetes (T2D). The data showed that tirzepatide produced better blood glucose control and body weight improvements with reduced risk of hypoglycemia, compared to degludec in these patients. Some...
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In a nutshell This study investigated the effectiveness and safety of re-irradiation for the treatment of patients with locally recurrent prostate cancer. The data showed that the use of re-irradiation in these patients was associated with good outcomes and low toxicity. Some background Radiotherapy (RT) is an effective treatment for localized...
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In a nutshell This study analyzed the effectiveness of extended robotic-assisted laparoscopic prostatectomy (eRALP) with extended pelvic lymph node dissection (ePLND) without any other additional treatments for patients with very-high-risk localized prostate cancer (PCa). The study found that eRALP with ePLND alone was safe and effective...
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In a nutshell This study evaluated the effectiveness of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) first-line treatment and performance status in older patients with EGFR-mutant non-small-cell lung cancer (NSCLC). The data showed that older patients with EGFR-mutated NSCLC who received EGFR-TKI first-line treatment with a...
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In a nutshell The review aimed to develop recommendations for stopping tyrosine kinase inhibitor (TKI) therapy in patients with chronic myeloid leukemia CML. Some background Tyrosine kinase inhibitors (TKI) are a type of targeted therapy. TKIs have improved the survival outcomes for patients with chronic myeloid...
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In a nutshell The authors compared the safety and effectiveness of lisocabtagene maraleucel (liso-cel; Breyanzi) and axicabtagene ciloleucel (axi-cel; Yescarta) in patients with relapsed or refractory (r/r) large B cell lymphoma (LBCL). The study found that both treatments were similarly effective but liso-cel was better tolerated in these...
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In a nutshell This study looked at the treatment of urinary incontinence (UI) with a combination of botulinum toxin (Botox) and polyacrylamide hydrogel (PAHG). This study showed that most patients achieved good UI control with this treatment. Some background UI (urine leakage) is a problem that affects many older women,...
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In a nutshell This study evaluated the optimal targets of blood pressure (BP) in older patients. It found that lowering systolic BP (SBP; BP when the heart beats) to 110-130 mmHg resulted in a lower risk of heart attack, stroke, or death compared to maintaining an SBP of 130-150 mmHg. Some background High blood pressure is a...
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