In a nutshell This study evaluated the effectiveness and safety of ixazomib (Ninlaro)-dexamethasone (Decadron) (ixa-dex) versus pomalidomide (Pomalyst)-dexamethasone (pom-dex) combination for the treatment of patients with relapsed or refractory (r/r) multiple myeloma (MM). The data showed that ixa-dex was safe and as effective as pom-dex...
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Comparing the effectiveness and safety of avanafil and sildenafil for the treatment of patients with erectile dysfunction.
In a nutshell This study compared the effectiveness and safety of avanafil (Stendra) with sildenafil (Viagra) for the treatment of patients with erectile dysfunction (ED). The data showed that avanafil had higher effectiveness compared to sildenafil in improving the symptoms of ED after 12 weeks. Some background Erectile dysfunction...
Read MoreComparing the effectiveness and safety between R-CHOP and modified NHL-BFM-90 regimens in children and adolescents with diffuse large B-cell lymphoma.
In a nutshell This study compared the effectiveness and safety of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) and modified non-Hodgkin lymphoma (NHL) Berlin-Frankfurt-Münster-90 (NHL-BFM-90; cyclophosphamide, vincristine, ifosfamide, etoposide, adriamycin, methotrexate, vindesine, dexamethasone, cytarabine)...
Read MoreLong-term safety and effectiveness of acalabrutinib with or without obinutuzumab versus obinutuzumab plus chlorambucil in patients with chronic lymphocytic leukemia
In a nutshell This study aimed to investigate the long-term safety and effectiveness of acalabrutinib (Calquence) with or without obinutuzumab (Gazyva) versus obinutuzumab with chlorambucil (Leukeran) in patients with chronic lymphocytic leukemia (CLL) that have never received treatment (treatment-naive). This study concluded that the...
Read MoreComparing effectiveness of intraoperative radiotherapy and whole breast irradiation in patients with early breast cancer
In a nutshell This study aimed to investigate the oncological effectiveness of intraoperative radiotherapy (IORT) and whole breast irradiation (WBI) for patients with early breast cancer (BC). This study concluded that there was a high oncological effectiveness for both groups of patients. Some background Intraoperative...
Read MoreEvaluating the risk of developing secondary rectal cancer after radiotherapy in patients with prostate cancer.
In a nutshell This study evaluated the risk of developing secondary rectal cancer after radiotherapy (RT) in patients with prostate cancer. The data showed that RT significantly increased the risk of developing secondary rectal cancer in these patients. Some background Prostate cancer (PCa) is one of the most common form of cancer found in men. PCa...
Read MoreComparing the effectiveness and safety of trastuzumab emtansine plus pertuzumab versus taxane plus trastuzumab plus pertuzumab in patients with high-risk HER2+ early breast cancer.
In a nutshell This study compared the effectiveness and safety of trastuzumab emtansine (T-DM1; Kadcyla) plus pertuzumab (Perjeta) versus taxanes plus trastuzumab (Herceptin) plus pertuzumab (THP) in patients with high-risk HER2-positive (+) early breast cancer (BC) after previous treatment with anthracycline-based chemotherapy. The data showed that...
Read MoreEvaluating the safety and effectiveness of optimized conformal total body irradiation in children with with blood cancer who received TCRαβ/CD19-depleted grafts
In a nutshell The study aimed to investigate optimized conformal (OC) total body irradiation (TBI) in pediatric patients with blood cancers who received further chemotherapy and allogeneic hematopoietic stem cell transplant (alloHSCT) with TCRαβ/CD19 depletion. This study concluded that OC-TBI is a...
Read MoreEvaluating the long-term effectiveness and safety of thulium laser enucleation of the prostate treatment for patients with benign prostatic hyperplasia.
In a nutshell This study evaluated the long-term effectiveness and safety of thulium laser enucleation of the prostate (ThuLEP) treatment for patients with benign prostatic hyperplasia (BPH). The data showed that ThuLEP treatment was safe and effective over the long term in these patients. Some background BPH is the non-cancerous increase in the size...
Read MoreEvaluating the effectiveness and safety of adding ixazomib to lenalidomide maintenance therapy in patients with newly diagnosed multiple myeloma after ASCT.
In a nutshell This study evaluated the effectiveness and safety of adding ixazomib (Ninlaro) to lenalidomide (Revlimid) maintenance therapy after autologous stem cell transplant (ASCT) in patients with newly diagnosed multiple myeloma (MM). The data showed that the addition of ixazomib to lenalidomide maintenance improved survival without cancer...
Read MoreEvaluating the effectiveness and safety of low-intensity extracorporeal shock wave therapy for patients with chronic pelvic pain syndrome and erectile dysfunction.
In a nutshell This study evaluated the effectiveness and safety of low-intensity extracorporeal shock wave therapy (LSWT) for patients with chronic pelvic pain syndrome (CPPS) and erectile dysfunction (ED). The data showed that LSWT was safe and effective in improving the symptoms of these patients. Some background CPPS is lower abdominal pain usually...
Read MoreEvaluating the effectiveness and feasibility of patient-reported outcome-based symptom management versus usual care in patients after lung cancer surgery.
In a nutshell This study evaluated the effectiveness and feasibility of patient-reported outcome (PRO)-based symptom management versus usual care in patients after lung cancer surgery. The data showed that PRO-based symptom management after lung cancer surgery showed lower symptom burden and fewer complications than usual care for up to 4 weeks after...
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