In a nutshell The study evaluated the effectiveness and safety outcomes of adding abiraterone acetate (AA; Zytiga) and prednisolone (P; Deltasone) with or without enzalutamide (Xtandi) to androgen-deprivation therapy (ADT) in patients with high-risk non-metastatic prostate cancer (PC). The data showed that AAP added to ADT significantly improved survival...
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Evaluating the benefits of a more versus a less intensive blood pressure lowering treatment strategy in patients with hypertension.
In a nutshell This study evaluated the benefits of a more versus a less intensive blood pressure (BP) lowering treatment strategy in patients with hypertension (high blood pressure). The data showed that a more intensive BP lowering treatment strategy significantly reduced the risks of stroke, heart failure, heart attacks, and cardiovascular death...
Read MoreEvaluating the effect of trimetazidine for the treatment of patients with ischemic heart disease who are not suitable for revascularization.
In a nutshell This study evaluated the effectiveness of trimetazidine (Vastarel) versus other anti-anginal drugs for the treatment of patients with ischemic heart disease (IHD) who are not suitable for revascularization. The data showed that trimetazidine improved walking time and angina attacks in these patients. Some background Coronary artery...
Read MoreEvaluating the long-term effectiveness and safety of device-aided therapies for the treatment of real-world patients with advanced Parkinson’s disease.
In a nutshell This study evaluated the long-term effectiveness and safety of device-aided therapies (DATs) for the treatment of real-world patients with advanced Parkinson’s disease (PD). The data showed that in the long-term, DATs are well maintained among these patients. Some background Parkinson's disease (PD) is a disorder in which part...
Read MoreEvaluating the impact of mid-urethral sling surgery and bulk injection therapy on sexual function in women with stress urinary incontinence.
In a nutshell This study evaluated the impact of mid-urethral sling (MUS) surgery and bulk injection (BI) therapy on sexual function in women with stress urinary incontinence (SUI). The study found that BI therapy and MUS surgery improved sexual function equally in sexually active women with SUI. Some background Stress urinary incontinence (SUI)...
Read MoreCan canagliflozin improve insulin resistance and internal fat tissue in patients with type 2 diabetes better than metformin?
In a nutshell This study assessed the effects of canagliflozin (Invokana) therapy on body composition, glucose control, insulin resistance, and systemic (whole body) inflammation in patients with newly-diagnosed type 2 diabetes (T2D) compared to metformin (Glucophage). The data showed that canagliflozin therapy reduced visceral fat tissue, and...
Read MoreEvaluating the effectiveness and safety of etoposide combined with cytarabine plus G-CSF for stem cell mobilization in patients with multiple myeloma.
In a nutshell This study evaluated the effectiveness and safety of etoposide (Etopophos) combined with cytarabine (Cytosar-U) plus granulocyte colony-stimulating factor (G-CSF, Neupogen) in patients with multiple myeloma (MM) for stem cell mobilization. The data showed that etoposide combined with cytarabine plus G-CSF was safe and effective for the...
Read MoreEvaluating the effectiveness and safety of Rezum water vapor therapy in real-world patients with benign prostatic hyperplasia.
In a nutshell This study evaluated the effectiveness and safety of Rezum water vapor therapy in real-world patients with benign prostatic hyperplasia (BPH). The data showed that Rezum water vapor therapy was safe and effective in these patients. Some background Benign prostatic hyperplasia (BPH) is a non-cancerous enlargement of the prostate...
Read MoreComparing the effectiveness of surgery with and without oral uracil and tegafur plus leucovorin chemotherapy for patients with stage II colon cancer.
In a nutshell This study compared the effectiveness of surgery with and without chemotherapy with uracil and tegafur (Uftoral; UFT) plus leucovorin (LV; folinic acid) in patients with stage II colon cancer. This study concluded that surgery with UFT/LV chemotherapy significantly improved survival outcomes in these patients. Some...
Read MoreEvaluating the effectiveness and safety of 225Ac-PSMA-617 after treatment with androgen deprivation therapy in patients with metastatic castration-resistant prostate cancer.
In a nutshell This study evaluated the effectiveness and safety of actinium-225 [225Ac]-PSMA-617 (225AcPSMA) after treatment with androgen deprivation therapy (ADT) in patients with metastatic castration-resistant prostate cancer (mCRPC). The data showed that 225AcPSMA treatment showed a higher response with manageable effects in these patients. Some...
Read MoreEvaluating the effectiveness and safety of first-line tyrosine kinase inhibitor with or without radiotherapy for the treatment of patients with oligometastatic EGFR-mutated NSCLC.
In a nutshell This study evaluated the effectiveness and safety of first-line tyrosine kinase inhibitors (TKIs) with or without radiotherapy (RT) for the treatment of patients with oligometastatic (OM) non-small-cell lung cancer (NSCLC) having genetic mutations in the epidermal growth factor receptor (EGFR). The data showed that TKI plus RT was safe and...
Read MoreEvaluating the effectiveness of immunochemotherapy treatments for advanced stage follicular lymphoma.
In a nutshell This study compared the effectiveness of common immuno-chemotherapy (ICT) treatments for advanced follicular lymphoma (FL) for front-line therapy. The study showed that obinutuzumab (Gazyva; G) combined with bendamustine (Treanda; Benda) (G-Benda-G regimen) had the best survival without cancer worsening in patients with advanced...
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