In a nutshell This study evaluated the effectiveness of daratumumab (Darzalex)-containing regimens in patients with multiple myeloma (MM) unresponsive to lenalidomide (Revlimid) maintenance therapy. The data showed that daratumumab-containing therapies are effective regimens in these patients. Some background Multiple myeloma (MM) is a type...
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Evaluating the effectiveness of adding dutasteride to tadalafil for improving lower urinary tract symptoms in patients with benign prostatic hyperplasia.
In a nutshell This study evaluated the effectiveness of adding dutasteride (Avodart) to tadalafil (Cialis) for the treatment of lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH). The data showed that adding dutasteride to tadalafil is a good treatment option for improving LUTS in these patients. Some background...
Read MoreEvaluating the effectiveness and safety of opicapone for the treatment of non-motor symptoms in patients with Parkinson’s disease.
In a nutshell This study evaluated the effectiveness and safety of opicapone (Ongentys) for the treatment of non-motor symptoms in patients with Parkinson's disease (PD). The data showed that opicapone improved the non-motor symptoms and quality of life (QoL) with manageable side effects in patients with PD. Some background Parkinson's disease...
Read MoreEvaluating the effectiveness and safety of sugemalimab after chemoradiotherapy in patients with unresectable stage III non-small cell lung cancer.
In a nutshell This study investigated the effectiveness and safety of sugemalimab (Cejemly) after treatment with concurrent or sequential chemoradiotherapy (CRT) in patients with unresectable stage III non-small cell lung cancer (NSCLC). The data showed that sugemalimab significantly increased the survival without cancer worsening with manageable...
Read MoreEvaluating the effect of total neoadjuvant therapy versus standard neoadjuvant chemoradiotherapy and planned adjuvant chemotherapy on the survival of patients with locally advanced rectal cancer.
In a nutshell This study investigated the effect of total neoadjuvant therapy (TNT) versus standard neoadjuvant chemoradiotherapy (CRT) and planned adjuvant chemotherapy on the survival of patients with locally advanced rectal cancer (LARC). The data showed that TNT did not increase survival compared with standard CRT and planned adjuvant...
Read MoreCan a combination of tamsulosin and herbal medicine improve lower urinary tract symptoms due to benign prostatic hyperplasia?
In a nutshell This study assessed the effectiveness and safety of combined therapy of tamsulosin (Flomax) and two different traditional herbal medicines in patients with lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). The study showed that tamsulosin with Ryutanshakanto provided pain relief in patients with chronic...
Read MoreEvaluating the effects of different antioxidants on the sperm quality and pregnancy rate of male infertility without a clear cause.
In a nutshell This study evaluated the effects of different antioxidants on sperm quality and the pregnancy rate of male infertility without a clear cause. The data showed that L-Carnitine had the highest probability of being the most effective antioxidant to increase sperm motility (movement) and sperm shape. ω-3 fatty acid had the highest...
Read MoreEvaluating the benefits of adding androgen deprivation therapy to radiation therapy and extending its duration in men with localized prostate cancer.
In a nutshell This study evaluated the benefits of adding androgen deprivation therapy (ADT) to radiation therapy (RT) and the benefit of extending the duration of ADT in men with localized prostate cancer (PCa). The data showed that the addition of ADT to RT and extending the duration of ADT administered after RT significantly improved the survival...
Read MoreEvaluating the effectiveness and safety of immunotherapy versus standard treatment options in patients with metastatic colorectal cancer.
In a nutshell This study compared the effectiveness and safety of immunotherapy versus standard treatment options in patients with metastatic colorectal cancer (mCRC). The data showed that immunotherapy tended to improve the survival outcomes in these patients. Some background Colorectal cancer (CRC) is one of the most common types of cancer...
Read MoreEvaluating the effectiveness of a second autologous hematopoietic cell transplantation performed with stem cells obtained after previous transplantation in patients with relapsed multiple myeloma.
In a nutshell This study evaluated the effectiveness of salvage autologous hematopoietic cell transplantation (ASCT) performed with stem cells obtained after previous transplantation in patients with relapsed multiple myeloma (MM). The data showed that salvage ASCT performed with stem cells remobilized after previous transplantation is a good treatment...
Read MoreEvaluating the effectiveness, durability, and safety of faricimab in patients with diabetic macular edema.
In a nutshell This study evaluated the effectiveness, durability, and safety of faricimab (Vabysmo) for the treatment of patients with diabetic macular edema (DME). The data showed that faricimab with extended dosing up to every 16 weeks was safe and showed good vision gains and clinical improvements in these patients. Some background...
Read MoreEvaluating the effectiveness and safety of darolutamide in combination with androgen deprivation therapy and docetaxel for metastatic hormone-sensitive prostate cancer.
In a nutshell This study evaluated the effectiveness and safety of darolutamide (Nubeqa) in combination with androgen deprivation therapy (ADT) and docetaxel (Taxotere) for the treatment of metastatic hormone-sensitive prostate cancer (mHSPC). The data showed that darolutamide in combination with ADT and docetaxel significantly improved the overall...
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