In a nutshell This study evaluated the benefits of radiation therapy (RT) dose escalation and the addition of short-term (ST) or long-term (LT) androgen deprivation therapy (ADT) to RT in men with localized prostate cancer (PCa). The data showed that the addition of ST or LT-ADT to RT improved survival without metastasis in these patients,...
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Combining anti-CD19 CAR T-cell therapy with ibrutinib for treating chronic lymphocytic leukemia
In a nutshell The study aimed to investigate if anti-CD19 chimeric antigen receptor (CAR) T-cell therapy and ibrutinib (Imbruvica) could be combined for the treatment of patients with chronic lymphocytic leukemia (CLL). This study concluded that adding anti-CD19 CAR T-cell therapy (CART-19) to ibrutinib treatment in these patients...
Read MoreComparing salvage intensive chemotherapy and venetoclax combined with low-intensity regimens in patients with relapsed/refractory acute myeloid leukemia
In a nutshell The study aimed to compare salvage intensive chemotherapy (IC) and a venetoclax (Venclexta; VEN)-combined low-intensity regimen in patients with relapsed/refractory (r/r) acute myeloid leukemia (AML). This study concluded that the VEN-combined regimen provided similar responses and survival rates when compared to...
Read MoreEvaluating the long-term effectiveness and safety of injections under the skin of daratumumab versus intravenous infusions for patients with relapsed or refractory multiple myeloma.
In a nutshell This study reported the final effectiveness and safety of subcutaneous (SC) injections versus intravenous (IV) infusions of daratumumab (Darzalex) in patients with relapsed or refractory multiple myeloma (MM). The data showed that daratumumab SC injections were as effective and caused fewer side effects than IV infusions over the long term...
Read MoreEvaluating the effectiveness and safety of continuous subcutaneous night-time only apomorphine for the treatment of insomnia in patients with Parkinson’s disease.
In a nutshell This study evaluated the effectiveness and safety of continuous subcutaneous night-time only apomorphine (Apokyn) infusion for the treatment of insomnia in patients with Parkinson’s disease (PD). The data showed that continuous subcutaneous night-time only apomorphine was effective in improving sleep disturbances in patients with...
Read MoreEvaluating the long-term effectiveness and safety of palbociclib plus fulvestrant treatment in patients with HR+/HER2- advanced BC.
In a nutshell This study evaluated the long-term effectiveness and safety of palbociclib (Ibrance) plus fulvestrant (Faslodex) in patients with hormone receptor-positive (HR+) and HER2-negative (HER2-) advanced breast cancer (BC). The data showed that adding palbociclib to fulvestrant was safe and significantly improved the overall survival over the...
Read MoreEvaluating the effectiveness and safety of venetoclax with dose-adjusted EPOCH-R as initial therapy for patients with aggressive B-cell lymphoma.
In a nutshell This study evaluated the effectiveness and safety of adding venetoclax (Venclexta) to a dose-adjusted EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin, and rituximab) regimen as initial therapy in patients with aggressive B-cell lymphoma. The data showed that venetoclax with dose-adjusted EPOCH-R was effective...
Read MoreEvaluating the short-term functional outcomes and safety of holmium and thulium fiber laser enucleation of the prostate treatment for patients with benign prostatic hyperplasia.
In a nutshell This study evaluated the short-term functional outcomes and safety of holmium (HoLEP) and thulium fiber laser enucleation of the prostate (ThuFLEP) treatment for patients with benign prostatic hyperplasia (BPH). The data showed that both HoLEP and ThuFLEP surgeries are similar in terms of functional outcomes and safety in these patients....
Read MoreEvaluating the renin-angiotensin-aldosterone system inhibitors effects on mortality and disease severity in patients with COVID-19
In a nutshell This review analyzed the effect of renin-angiotensin-aldosterone system (RAAS) inhibitors including angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) on patient prognosis for COVID-19. The data suggested that there is no association between the use of ACEIs/ARBs and the risk of mortality and...
Read MoreA review of the effect of vitamin E supplementation in patients with rheumatoid arthritis.
In a nutshell This review evaluated the safety and effectiveness of vitamin E supplementation in patients with rheumatoid arthritis (RA). The authors concluded that regular supplementation with vitamin E can help to improve the overall quality of life (QoL) in patients by reducing joint discomfort, swelling due to excessive fluid buildup in tissues...
Read MoreEvaluating ponatinib treatment in any phase of treatment in patients with chronic myeloid leukemia resistant or intolerant to other tyrosine kinase inhibitors
In a nutshell This study aimed to investigate the safety and effectiveness of ponatinib (Iclusig) in patients with chronic myeloid leukemia (CML) who were resistant or intolerant to previous tyrosine kinase inhibitors (TKIs). This study concluded that ponatinib was effective in heavily pretreated patients when administered in any phase of...
Read MoreEvaluating the long-term outcomes of radiotherapy added to standard therapy for men with metastatic prostate cancer.
In a nutshell The study investigated whether radiotherapy (RT) addedd to standard of care (SOC) treatment would be beneficial for men with metastatic (spread) prostate cancer (mPC). The study showed that adding RT to SOC improved the survival of men with low burden (defined as fewer than 10 lesions, no greater than 3cm in diameter) mPC. Some...
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