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Comparing the effectiveness and safety of combined therapy of pertuzumab with trastuzumab versus single trastuzumab therapy in patients with HER2-positive advanced breast cancer

Comparing the effectiveness and safety of combined therapy of pertuzumab with trastuzumab versus single trastuzumab therapy in patients with HER2-positive advanced breast cancer

Posted by on Nov 14, 2022 in Breast cancer | 0 comments

In a nutshell The study compared the effectiveness and safety of pertuzumab (Perjeta) and trastuzumab (Herceptin) combined therapy with trastuzumab alone in patients with HER2-positive (HER2+) advanced breast cancer (BC). The study found that the combined therapy was more effective and well tolerated compared to single therapy in...

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Comparing salvage and primary holmium laser enucleation of the prostate in patients with benign prostatic hyperplasia.

Comparing salvage and primary holmium laser enucleation of the prostate in patients with benign prostatic hyperplasia.

Posted by on Nov 5, 2022 in Benign prostatic hyperplasia | 0 comments

In a nutshell This study compared the safety and effectiveness of salvage (S) and primary (P) holmium laser enucleation of the prostate (HoLEP) in patients with benign prostatic hyperplasia (BPH). It also evaluated what were the procedures leading to S-HoLEP in these patients. The authors concluded that S-HoLEP was similar to...

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Is dorzagliatin an effective add-on treatment to metformin in patients with type 2 diabetes?

Is dorzagliatin an effective add-on treatment to metformin in patients with type 2 diabetes?

Posted by on Nov 5, 2022 in Diabetes mellitus | 0 comments

In a nutshell This study assessed the effectiveness and safety of adding dorzagliatin (HMS552) to metformin therapy in patients with type 2 diabetes (T2D) with inadequately controlled blood glucose (sugar) while using metformin (Glucophage) alone. The data showed effective blood glucose control, good tolerance, and safety in patients...

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Evaluating the safety and effectiveness of tebentafusp in previously treated patients with advanced uveal melanoma

Evaluating the safety and effectiveness of tebentafusp in previously treated patients with advanced uveal melanoma

Posted by on Oct 25, 2022 in Melanoma | 0 comments

In a nutshell The study evaluated the safety and effectiveness of tebentafusp (Kimmtrak) in patients with metastatic uveal melanoma who had received previous treatments. The study found that tebentafusp had promising effectiveness and a good safety profile in these patients. Some background Uveal melanoma is a rare and aggressive eye tumor....

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Evaluating the effectiveness and safety of adebrelimab plus standard chemotherapy as first-line treatment for extensive-stage small cell lung cancer.

Evaluating the effectiveness and safety of adebrelimab plus standard chemotherapy as first-line treatment for extensive-stage small cell lung cancer.

Posted by on Oct 16, 2022 in Lung cancer | 0 comments

In a nutshell This study investigated the effectiveness and safety outcomes of adebrelimab (SHR-1316) plus carboplatin (Paraplatin) and etoposide (Etopophos)-based chemotherapy as first-line treatment for extensive-stage (ES) small-cell lung cancer (SCLC). The data showed that adebrelimab added to standard chemotherapy as first-line treatment...

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Evaluating the effectiveness of tadalafil alone, silodosin alone, and the combination of both in the treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia.

Evaluating the effectiveness of tadalafil alone, silodosin alone, and the combination of both in the treatment of lower urinary tract symptoms in patients with benign prostatic hyperplasia.

Posted by on Oct 16, 2022 in Benign prostatic hyperplasia | 0 comments

In a nutshell This study evaluated the effectiveness of tadalafil (Cialis) alone, silodosin (Rapaflo) alone, and the combination of both in the treatment of lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH). The data showed that a combination of tadalafil plus silodosin is more effective than either drug alone in...

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A review of mRNA COVID-19 vaccines in patients with chronic lymphocytic leukemia

A review of mRNA COVID-19 vaccines in patients with chronic lymphocytic leukemia

Posted by on Oct 16, 2022 in Leukemia | 0 comments

In a nutshell This review aimed to assess the strength of previous evidence and to better understand the current role of SARS-CoV-2 vaccination in patients with chronic lymphocytic leukemia (CLL).  This review concluded that there is an overall lower seroconversion rate for SARS-CoV-2 vaccination in these patients as compared with the general...

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Comparing the effectiveness and safety of prostate-only versus pelvic radiotherapy for patients with prostate cancer spread to nearby lymph nodes.

Comparing the effectiveness and safety of prostate-only versus pelvic radiotherapy for patients with prostate cancer spread to nearby lymph nodes.

Posted by on Oct 16, 2022 in Prostate cancer | 0 comments

In a nutshell This study compared the safety and effectiveness of whole-pelvis radiotherapy (WPRT) and prostate-only radiotherapy (PORT) in patients with node-positive prostate cancer (PC) (PC that has spread to nearby lymph nodes). The study found that WPRT improves survival without relapse in these patients, with more short-term...

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Is the addition of low-dose prednisolone more beneficial than harmful to older patients with rheumatoid arthritis?

Is the addition of low-dose prednisolone more beneficial than harmful to older patients with rheumatoid arthritis?

Posted by on Oct 16, 2022 in Rheumatoid Arthritis | 0 comments

In a nutshell This study assessed the effectiveness and safety of daily administered prednisolone (Prelone) at a dose of 5 mg, as an add-on to the standard of care (SOC) in older patients with rheumatoid arthritis (RA). The authors concluded that low-dose prednisolone added to SOC had long-term benefits in these patients with a favorable balance of...

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How safe and effective is dapagflozin in patients with type 2 diabetes based on blood pressure levels?

How safe and effective is dapagflozin in patients with type 2 diabetes based on blood pressure levels?

Posted by on Oct 16, 2022 in Diabetes mellitus | 0 comments

In a nutshell This study analyzed the safety and effectiveness of dapagliflozin (Farxiga) in patients with type 2 diabetes (T2D) across different ranges of baseline systolic blood pressure (SBP; blood pressure when the heart beats). The data suggested that dapagliflozin reduced the risk of hospitalization for heart failure (HHF) and kidney-related...

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Comparing the effectiveness and safety of an early versus a delayed invasive strategy in patients with non-ST elevation acute coronary syndrome.

Comparing the effectiveness and safety of an early versus a delayed invasive strategy in patients with non-ST elevation acute coronary syndrome.

Posted by on Oct 13, 2022 in Coronary artery disease | 0 comments

In a nutshell This study compared the effectiveness and safety of an early and a delayed invasive strategy (IS) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). The data showed that there were no significant differences in the risk of death, heart attacks, stroke rates, major bleeding, or revascularization between early and delayed...

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