In a nutshell This study evaluated the effectiveness and safety of adding oxaliplatin (Eloxatin; 3 months vs 6 months) to 6 months of fluoropyrimidine therapy such as 5-Fluorouracil (Adrucil) or capecitabine (Xeloda) as adjuvant (treatment after surgery) treatment in patients with stage II or III colon cancer. The data showed that adding 3 months of...
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Evaluating the effectiveness and safety of anlotinib as a third-line treatment in patients with advanced NSCLC.
In a nutshell This study evaluated the effectiveness and safety of anlotinib (AL3818) as a third-line treatment in patients with advanced non-small cell lung cancer (NSCLC). The data showed that anlotinib as a third-line treatment was effective with manageable side effects in these patients. Some background NSCLC is the most common form of lung...
Read MoreEvaluating the long-term effectiveness and safety of bosutinib versus imatinib in patients with newly diagnosed chronic phase chronic myeloid leukemia.
In a nutshell This study evaluated the long-term effectiveness and safety of bosutinib (Bosulif) versus imatinib (Gleevec) in patients with newly diagnosed chronic phase (CP) chronic myeloid leukemia (CML). The data showed that bosutinib had better effectiveness than imatinib in these patients. Some background CML is a type of cancer that starts...
Read MoreComparing the effectiveness and safety between biodegradable and durable polymer drug-eluting stents in patients with acute coronary syndrome.
In a nutshell This study compared the effectiveness and safety between biodegradable polymer (BP) drug-eluting stents (DES) and durable polymer (DP) DESs in patients with acute coronary syndrome (ACS). The data showed that both stent types demonstrated excellent effectiveness and safety after 1 year. The authors suggested that BP-DES may be more...
Read MoreEvaluating the effectiveness of fulvestrant plus capivasertib in patients with aromatase inhibitor-resistant estrogen receptor-positive, HER2-negative advanced breast cancer.
In a nutshell This study evaluated the effectiveness of fulvestrant (Faslodex) plus capivasertib (AZD5363) in patients with aromatase inhibitor-resistant estrogen receptor-positive (ER+) and HER2-negative (HER2-) advanced breast cancer (BC). The data showed that fulvestrant plus capivasertib significantly improved the survival outcomes in these...
Read MoreComparing the safety of palbociclib combined with fulvestrant or letrozole in HR+/HER2- advanced breast cancer
In a nutshell This study evaluated the safety profile of palbociclib (Ibrance) combined with either fulvestrant (Faslodex) or letrozole (Femara) in patients with hormone-receptor-positive (HR+) and HER2 negative (HER2 -) advanced breast cancer (BC). The data showed that both palbociclib regimens were safe and tolerated in these patients with some...
Read MoreComparing the effectiveness of IVF/ICSI versus IUI in unexplained infertility
In a nutshell The study compared the pregnancy rates for intrauterine insemination (IUI) and in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) in couples with unexplained infertility. The data concluded that IVF/ICSI is a better treatment option than IUI for unexplained infertility. Some background Infertility is the inability to...
Read MoreEvaluating the effectiveness of intralipid administration to improve in vitro fertilization outcomes
In a nutshell The study evaluated the effectiveness of intralipid administration to improve in vitro fertilization (IVF) outcomes. The main finding was that injecting intralipid in women during IVF showed promising results in improving pregnancy and live birth rates. Some background Infertility is faced by many couples and IVF is one way to achieve...
Read MoreComparing the effectiveness of TAS-102 versus regorafenib for the treatment of patients with metastatic colorectal cancer.
In a nutshell This study compared the effectiveness of TAS-102 (Lonsurf; trifluridine-tipiracil) versus regorafenib (Stivarga) for the treatment of patients with metastatic colorectal cancer (mCRC). The data showed that TAS-102 had better oncologic outcomes than regorafenib in these patients. Some background Colorectal cancer (CRC) is one of the...
Read MoreEvaluating the effectiveness and safety of ramucirumab and pembrolizumab versus standard of care in previously treated patients with advanced NSCLC.
In a nutshell This study investigated the effectiveness and safety outcomes of ramucirumab (Cyramza) and pembrolizumab (Keytruda) versus standard of care (SOC) in previously treated patients with advanced non-small cell lung cancer (NSCLC). The data showed that ramucirumab and pembrolizumab significantly improved overall survival compared with SOC in...
Read MoreCan icosapent ethyl prevent cardiovascular events and mortality in patients that have had previous heart attacks?
In a nutshell This study examined the effect of icosapent ethyl (IPE; Vascepa) on major cardiovascular events (MACEs) in statin-treated patients that had previous heart attacks (myocardial infarction; MI). The data showed that patients treated with IPE had large and significant reductions in MACEs. Some background Ischemic events are associated with a...
Read MoreEvaluating the effectiveness of combining low-intensity extracorporeal shock wave therapy with vacuum erectile device for the treatment of patients with diabetes and erectile dysfunction.
In a nutshell This study evaluated the effectiveness of combining low-intensity extracorporeal shock wave therapy (Li-ESWT) with a vacuum erectile device (VED) for the treatment of patients with diabetes mellitus (DM) and erectile dysfunction (ED) who were unresponsive to phosphodiesterase-5 (PDE5) inhibitors. The data showed that Li-ESWT combined with...
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