In a nutshell The study aimed to investigate whether reduced-intensity conditioning (RIC) hemopoietic stem cell transplantation (HSCT) improves the outcomes of patients with chronic lymphocytic leukemia (CLL) with and without Richter's transformation (RT). This study concluded that this treatment may be suitable in early...
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Searching for patients with previously untreated chronic lymphocytic leukemia to try a treatment combination
In a nutshell This trial is comparing the effectiveness of a combined regimen of venetoclax (Venclexta) and obinutuzumab (Gazyva) or VEN-G to an existing drug regimen of fludarabine (Fludara), cyclophosphamide (Cytoxan), and rituximab (Rituxan) or FCR, or bendamustine (Treanda) and rituximab...
Read MoreLooking for patients to try a treatment combination for untreated chronic lymphocytic leukemia.
In a nutshell This study is searching for patients with previously untreated chronic lymphocytic leukemia (CLL) to try a new treatment combination containing obinutuzumab (Gazyva) or obinutuzumab/bendamustine (Treanda) to shrink the tumor (debulking) before treatment with venetoclax (Venclexta). The main outcome that will be measured is the number...
Read MoreCombining obinutuzumab and bendamustine for chronic lymphocytic leukemia patients
In a nutshell This study aimed to investigate the effectiveness of an obinutuzumab and bendamustine combination in chronic lymphocytic leukemia patients. This study concluded that this combination appears to be effective in these patients and has manageable side effects. Some background Obinutuzumab (Gazyva) is a monoclonal antibody. Monoclonal...
Read MoreRelapse on ibrutinib linked to genetic changes in BTK and PLCG2
In a nutshell This study examined the association between specific genetic changes (mutations) and disease relapse with ibrutinib (Imbruvica) in patients with chronic lymphocytic leukemia (CLL). Researchers reported that the mutations BTK and PLCG2 appear early and could be used as a predictor for future relapse on ibrutinib. Some background The...
Read MoreLooking for patients with untreated chronic lymphocytic leukemia to test an ibrutinib and fludarabine treatment
In a nutshell This phase 2 clinical trial will test the safety and effectiveness of an ibrutinib (Imbruvica) and fludarabine (Fludara) treatment in patients with previously untreated chronic lymphocytic leukemia (CLL). The primary outcome will be measured by the safety and effectiveness of the treatment. The details Ibrutinib is a drug that...
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