In a nutshell This phase 2 study will investigate the effectiveness of experimental medication tucatinib and trastuzumab (Herceptin) to treat brain metastases in HER2-positive breast cancer (BC). The main outcome will be overall survival (OS). This trial is recruiting in Alabama and Texas, the US. The details...
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Alectinib vs crizotinib in treating brain or spinal cord tumors in patients with non-small cell lung cancer
In a nutshell This study wanted to find out which medication is better for treating lung cancer that has spread to the brain or spinal cord, crizotinib (Xalkori) or alectinib (Alecensa). The study found that alectinib worked better than crizotinib for treatment of tumors of the brain and spinal cord. Some background Alectinib and crizotinib are two...
Read MoreA treatment option for advanced breast cancer patients with visceral metastasis
In a nutshell This study aimed to investigate the benefits of fulvestrant (Faslodex) treatment in advanced breast cancer patients. This study concluded that fulvestrant provides a benefit in patients with advanced breast cancer who have visceral metastasis. Some background Advanced breast cancer (ABC) has spread to the lymph nodes and...
Read MoreEarly results of an anti-angiogenic drug in treating advanced prostate cancer
In a nutshell This study investigated cabozantinib (Cometriq), an anti-angiogenic drug, in the treatment of advanced and progressing prostate cancer. Researchers report preliminary evidence for cabozantinib in reducing disease progression and cancer pain. Some background Tumors need to be able to grow new blood vessels in order to grow....
Read MoreTraditional Chinese medicine; the effects on breast cancer survival
In a nutshell The authors aimed to assess the effectiveness of traditional Chinese medicine used with conventional breast cancer treatments on breast cancer survival. Some background Traditional Chinese medicine is an alternative therapy that can complement breast cancer treatments. This generally includes various forms of herbal medicine,...
Read MoreSurgical treatment for abdominal melanoma metastases
In a nutshell This study evaluated the effectiveness of surgery to remove abdominal melanoma metastatic lesions. In addition, the study proposes a new method of predicting surgery outcomes. Some background Melanoma is a type of malignant skin cancer which has a high tendency to metastasize (spread into distant organs). While patients with...
Read MoreImproved survival with vemurafenib in patients with metastatic melanoma
In a nutshell In this phase 3 clinical trial, researchers compared the safety and efficacy of vemurafenib to the standard chemotherapy drug for melanoma, dacarbazine. Some background A genetic defect (mutation) in protein called BRAF is present in approximately 50% of melanomas. BRAF helps cells grow and multiply, so BRAF mutations are responsible...
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