In a nutshell This study evaluated the effectiveness and safety of TAS-102 (Lonsurf; trifluridine-tipiracil) plus Yttrium-90 (Y-90) radioembolization (RE) for patients with colorectal cancer liver metastasis (CRLM) who are unresponsive to chemotherapy. The data showed that TAS-102 plus RE was safe and effective in these patients. Some background...
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Adding everolimus to letrozole in premenopausal patients with hormone-positive advanced breast cancer
In a nutshell This study evaluated the effects and outcomes of adding everolimus (EVE; Afinitor) plus letrozole (LET; Femara) to hormonal therapy for the treatment of premenopausal women with hormone receptor-positive (HR+), HER2-negative (HER2-) advanced breast cancer (BC). The data showed that the combination of EVE+LET improved survival...
Read MoreA review on regional therapies for colorectal cancer liver metastases
In a nutshell This study reviewed regional treatment options for patients with colorectal cancer (CRC) and liver metastases (LM; spread to the liver). Some background CRC is the third most common cancer in the world. The most common organ where the cancer spreads is the liver. Surgery is the standard treatment for LM....
Read MoreComparing surgery options for patients with colorectal cancer that has spread to the liver
In a nutshell The aim of this study was to evaluate 2 treatment options for patients with colorectal cancer (CRC) that has spread to the liver. The study found that patients who underwent associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) had better outcomes compared to those who had 2-stage hepatectomy...
Read MoreBevacizumab plus chemotherapy and deep electro-hyperthermia improves the outcomes of patients with advanced colon cancer
In a nutshell This study investigated the effectiveness of bevacizumab plus chemotherapy and deep electro-hyperthermia (DEH) for advanced colon cancer (CC). Researchers suggested that this treatment improves the outcomes of these patients. Some background Colorectal cancer is a common cancer worldwide. Around 50-60% of these patients...
Read MoreAre immune checkpoint inhibitors effective for non-small-cell lung cancer spread to the brain or liver?
In a nutshell This study was carried out to look at the effectiveness of immune checkpoint inhibitors (ICI) in non-small cell cancer (NSCLC) patients with different sites of cancer spread. The authors found that ICIs could significantly improve the overall survival (OS) of patients NSCLC spread to the brain or liver compared to conventional...
Read MoreEvaluating the timing of chemotherapy plus bevacizumab for patients with colorectal cancer and liver metastasis
In a nutshell This study investigated whether chemotherapy plus bevacizumab (Avastin) before and after or after surgery improves the survival of patients with colorectal cancer (CRC) and operable liver metastasis (LM; cancer spread to the liver). Researchers suggested that chemotherapy and bevacizumab before and after...
Read MoreBevacizumab plus mFOLFOX6 improves the outcomes of patients with colorectal cancer and liver metastasis
In a nutshell This study investigated the effects of bevacizumab (Avastin) combined with mFOLFOX6 (fluorouracil, leucovorin, and oxaliplatin) treatment in RAS-positive advanced colorectal cancer (CRC). Researchers suggested that this treatment improved the treatment and survival outcomes of patients with CRC and liver metastasis (spread to the...
Read MoreMetastasis surgery improves survival of patients with advanced colorectal cancer
In a nutshell This study investigated the survival outcomes of patients who underwent surgery for colorectal cancer (CRC) metastasis (spread to other parts of the body). Researchers suggested that metastasis surgery is associated with survival improvement in these patients. Some background CRC is one of the most common cancers worldwide. A...
Read MoreRobotic versus laparoscopic liver surgery is a safe treatment for metastatic colorectal cancer
In a nutshell This study investigated the effectiveness of robotic-assisted liver surgery (RALS) compared to laparoscopic liver surgery (LLS) in advanced colorectal cancer. Researchers suggested that RALS is similarly safe and effective as LLS for these patients. Some background Colorectal cancer is one of the most common cancers worldwide....
Read MoreLooking for participants to test a vaccine for the treatment of advanced colorectal cancer
In a nutshell This phase 1b trial is examining the effectiveness and safety of a vaccine treatment, ATP128, in the treatment of advanced colorectal cancer. The main outcome to be measured is the tumor response to the treatment and treatment toxicity. This trial is being conducted in Arizona and California, US. The details Colorectal cancer is the...
Read MoreLiver surgery is a safe treatment for patients with BRAF-positive colorectal cancer liver metastasis
In a nutshell This study investigated the outcomes of patients with BRAF-positive colorectal cancer liver-metastasis (CRLM; spread to the liver) undergoing surgery. Researchers suggested that surgery is associated with improved outcomes for these patients. Some background Colorectal cancer is one of the most common cancers in the US. Around 25% of...
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