In a nutshell The authors evaluated the factors that could predict development of brain metastasis in melanoma patients. Some background In advanced melanoma, cancer often spreads to the brain (brain metastasis). The functional changes in the body that accompany the symptoms of brain metastasis are currently unknown. However, if patients are...
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In a nutshell The authors reviewed the effectiveness of a group of drugs called epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) in non-small cell lung cancer (NSCLC) brain metastasis (cancer that has spread from the lungs to the brain). Some background There is a 20-40% risk that NSCLC will spread from the lung to the brain....
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In a nutshell The objective of this study was to evaluate the effect of erlotinib (Tarceva) in combination with pemetrexed (Alimta) and cisplatin (Platinol) in lung cancer that had spread into the brain (brain metastases). Some background Lung adenocarcinoma is the cancer of glandular cells of lungs. It is a common type of non-small cell lung...
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In a nutshell This paper studied factors that could predict outcome in patients with human epidermal growth factor receptor 2 (HER2) breast cancer that has spread to the brain. Some background HER2 positive breast cancer refers to breast cancer in which there are high levels of the protein, HER2, on cancer cells. Trasutuzumab...
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In a nutshell This study analyzed the characteristics and survival of patients with colorectal cancer that had spread to the brain. Some background In a relatively low number of cases cancer can metastasize (spread) to the brain. Most patients with brain metastases will suffer from symptoms including memory problems, language...
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In a nutshell This paper reviewed treatments for human epidermal growth factor receptor 2 positive (presence of HER2, a protein on cancer cells) breast cancer that has metastasized (spread) to the brain. Some background Human epidermal growth factor receptor 2 (HER2) is a receptor that can be found on cancer cells. HER2 positive breast...
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In a nutshell The authors aimed to determine whether dacarbazine was better as a single or combination therapy when treating malignant melanoma. Some background Dacarbazine (DTIC) has been the most used and effective treatment option in malignant melanoma, however it has a low response rate (reduction in the signs or symptoms of cancer) of...
Read MoreIn a nutshell This paper studied methods of treatment in breast cancer brain metastasis. Some background Breast cancer brain metastasis is cancer that has spread from the breast to the brain and is associated with poor prognosis (outlook). The overexpression of human epidermal growth factor receptor 2 (HER2, a protein on cells)...
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In a nutshell This study was a phase I clinical trial that tested the safety and efficacy of Dabrafenib in melanoma patients with brain metastases (melanoma that has spread to the brain). Results showed that the drug had manageable side effects and improved progression-free survival. Some background Metastatic melanoma means that the cancer has...
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