In a nutshell This study evaluated the effects and outcomes of adding everolimus (EVE; Afinitor) plus letrozole (LET; Femara) to hormonal therapy for the treatment of premenopausal women with hormone receptor-positive (HR+), HER2-negative (HER2-) advanced breast cancer (BC). The data showed that the combination of EVE+LET improved survival...
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Evaluating the effectiveness of enzalutamide plus androgen deprivation therapy in metastatic hormone-sensitive prostate cancer by pattern of metastatic spread
In a nutshell This study examined the impact of the pattern of metastatic spread on the effectiveness of enzalutamide in combination with androgen deprivation therapy (ADT) for the treatment of metastatic hormone-sensitive prostate cancer (mHSPC). The data showed that the combination has good outcomes in men with bone and/or lymph node...
Read MoreEvaluating palbociclib plus hormonal therapy for advanced breast cancer spread to the bone.
In a nutshell This trial was carried out to analyze whether the length of time without treatment and the length of time without active disease influences the survival of patients with advanced breast cancer (ABC) spread to the bone taking palbociclib (Ibrance) plus hormonal therapy (HT). The authors concluded...
Read MoreCan bisphosphonates improve treatment outcomes for patients with lung cancer spread to the bones?
In a nutshell This study evaluated whether zoledronate (Zometa) combined with TKI therapy is more effective than TKI therapy alone for patients with non-small cell lung cancer (NSCLC) spread to the bones. This study concluded that adding zoledronate to TKI therapy improved survival outcomes for these patients. Some background NSCLC is the most common...
Read MoreEvaluating the safety of re-treatment with radium-223
In a nutshell This study aimed to evaluate the safety and effectiveness of radium-223 (Xofigo, formerly known as Alpharadin) in patients with advanced prostate cancer that has spread to the bones and who have had this treatment previously. This study found that re-treatment with radium-223 was well tolerated and with good results. Some background...
Read MoreHow effective is radiotherapy for the treatment of advanced prostate cancer?
In a nutshell This study investigated the effectiveness of prostate radiotherapy (RT) in prostate cancer (PC). They found that prostate RT may improve survival in men with PC and fewer than 5 bone metastasis (cancer that has spread to the bones). Some background Prostate cancer (PC) is a common and treatable cancer in men. One common type...
Read MoreLooking for men with prostate cancer to test chemotherapy in combination with radiotherapy
In a nutshell This trial evaluates the effectiveness of using chemotherapy in combination with radium-223 (a type of internal radiotherapy). The main outcome to be measured is overall survival. This trial is taking place in the United States. The details Prostate cancer is an uncontrolled growth of the cells which make up the prostate gland. Prostate...
Read MoreAbiraterone plus prednisone therapy in men with advanced prostate cancer
In a nutshell The authors aimed to determine the benefit of abiraterone acetate (Zytiga) plus prednisone (Deltasone) with hormone therapy in men with newly diagnosed, advanced prostate cancer. The authors concluded that adding abiraterone acetate plus prednisone to hormone therapy significantly increased overall survival and progression-free survival...
Read MoreCancer spread to the spine: Predictors of survival
In a nutshell This study examined predictors of survival for cancer patients with spinal bone metastases. Authors reported that stable and unstable spinal bone metastases had similar survival rates. However, factors predictive of survival were different between groups. Some background When cancer spreads outside of the prostate (known as...
Read MoreCancer spread to the spine: Predictors of survival
In a nutshell This study examined predictors of survival for cancer patients with spinal bone metastases. Authors reported that stable and unstable spinal bone metastases had similar survival rates. However, factors predictive of survival were different between groups. Some background When cancer spreads outside of the lung (known as...
Read MoreCancer spread to the spine: Predictors of survival
In a nutshell This study examined predictors of survival for cancer patients with spinal bone metastases. Authors reported that stable and unstable spinal bone metastases had similar survival rates. However, factors predictive of survival were different between groups. Some background When cancer spreads outside of the breast (known as...
Read MoreRadiation therapy drugs effective in treating bone pain
In a nutshell This review examined the effects of different radiopharmaceuticals in reducing bone pain in advanced prostate cancer. Researchers concluded that radiopharmaceuticals were associated with a significant reduction in bone pain. Some background When prostate cancer spreads outside of the prostate (also called metastatic prostate cancer),...
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