In a nutshell This study compared different treatments for patients with chronic myelomonocytic leukemia (CMML). The data showed that hypomethylating agents (HMA) improved the outcomes compared with other treatments in these patients. Some background Chronic myelomonocytic leukemia (CMML) is a type of cancer that starts in blood-forming...
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In a nutshell This study aimed to investigate if postinduction central nervous system (CNS; brain and spine) protection with intrathecal (injection into the spine) triple therapy (ITT) would improve the outcomes for pediatric patients with acute lymphoblastic leukemia (ALL) when compared to intrathecal methotrexate (MTX; Otrexup)...
Read MoreIn a nutshell This phase 2 trial is evaluating the effectiveness of huCART19 cell therapy in young patients with high-risk B-cell acute lymphoblastic leukemia (ALL). The main outcome to be measured will be survival without a treatment-related complication. This study is being conducted in Philadelphia, Pennsylvania, United States. The details Acute...
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In a nutshell This study observed the safety and effectiveness of the drug Gemtuzumab Ozagamicin (Mylotarg) when given to children with acute myeloid leukemia unresponsive to treatment. The authors found the treatment to be effective in children who became unresponsive to bone marrow transplant therapy. Some background Acute Myeloid...
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In a nutshell This study aimed to identify risk factors leading to a longer hospital stay in children being treated with chemotherapy for high-risk acute lymphoblastic leukemia (ALL). The study found that a high amount of young patients treated for high-risk ALL experienced a longer hospital stay. Some background Acute lymphoblastic leukemia...
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In a nutshell This study examined causes and outcomes of a chromosomal abnormality known as 17p deletion in chronic lymphocytic leukemia (CLL). Researchers reported poor outcomes for patients that have both 17p deletion and 8q24 gain. Some background Certain genetic changes in CLL can make it more difficult to treat. Changes in the chromosomes, such...
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In a nutshell This study reviewed CAR-T cell therapy, a new type of immunotherapy, for chronic lymphocytic leukemia (CLL). Some background Chimeric antigen receptor (CAR) T-cell therapy helps the immune system to fight cancer cells. In this treatment, immune cells (the T-cells) are removed from the blood. The T-cells are then genetically modified...
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In a nutshell This study analyzed the results of 37 studies comparing myeloablative therapy and reduced intensity conditioning (RIC) before stem cell transplantation in patients with chronic lymphocytic leukemia (CLL). This study concluded that RIC was associated with lower mortality and better survival compared to myeloablative therapy. Some...
Read MoreIn a nutshell This study examined predictors of outcomes with stem cell transplantation from a donor (allo-SCT) for chronic lymphocytic leukemia (CLL). Researchers reported good long-term outcomes for young high-risk CLL patients treated with allo-SCT. Patients with matched sibling donors showed better outcomes compared to those with matched unrelated...
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In a nutshell This study examined stem cell transplant outcomes across acute myeloid leukemia (AML) patients with different disease status. Researchers reported superior survival after a stem cell transplant among patients in second complete remission. Some background Stem cell transplantation is considered the most effective therapy for...
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In a nutshell This study looked at the safety and effectiveness of donor stem cell transplantation in chronic lymphocytic leukemia (CLL) patients who have not responded well to previous treatments. The authors concluded that stem cell transplants can lead to long-term minimal residual disease-free survival for up to one-half of patients. Some...
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