In a nutshell This review assessed the effect of vitamin B12 supplementation on clinical outcomes when used alone or combined with other treatments for diabetic peripheral neuropathy (PN). The authors concluded that a greater reduction of PN symptoms occurred with the use of B12 supplementation alone or in combination with other treatments compared to...
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In a nutshell This study evaluated the effectiveness and safety of a shorter dual antiplatelet therapy (DAPT) duration after percutaneous coronary intervention (PCI) using drug-eluting stents (DES) in patients with acute or recent myocardial infarction (MI; heart attack) at high bleeding risk. The data showed that a shorter DAPT duration (1 month)...
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In a nutshell This study evaluated the effects of aquatic physical therapy on improvement in fatigue symptoms and quality of life (QoL) in patients with breast cancer (BC). The data showed that aquatic physical therapy reduced fatigue symptoms and improved the QoL in women with BC. Some background Breast cancer (BC) is one of the most common...
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In a nutshell This study looked at the use of metformin (Glucophage) for the management of type 2 diabetes (T2D) in pregnancy. The study showed that compared to infants exposed to placebo, those exposed to metformin during pregnancy did not show any signs of increased weight or body mass index (BMI; a measurement of weight in relation to...
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In a nutshell The study evaluated the effectiveness and safety of robot-assisted artificial urinary sphincter (AUS) implantation surgery in women with severe stress urinary incontinence (SUI). The data found that women with severe SUI showed great improvement with robot-assisted AUS but there was an increased rate of complications. Some background SUI...
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In a nutshell This review assessed the effectiveness and safety of ultra-rapid insulin analogs (URIAs) with continuous subcutaneous insulin systems (CSII) in adults with type 1 diabetes (T1D). The authors concluded that URIAs were compatible with CSII systems and had a better glucose-lowering effect after meals compared to rapid-acting insulin...
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In a nutshell This study evaluated the cost-effectiveness of low-dose prednisolone (Omnipred) at 5 mg daily in the treatment of patients with rheumatoid arthritis (RA) aged 65 years or more. The study found that a low dose of prednisolone was an effective add-on treatment for patients with RA based on similar or lower costs compared to a placebo for...
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In a nutshell This study analyzed the long-term effect of behavioral counseling on increasing daily physical activity (PA) and reducing sedentary (SED) time on changes in beta-cell (β-cell) function and glucose control in patients with type 2 diabetes (T2D). The authors concluded that increasing moderate-to-vigorous-intensity physical activity...
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In a nutshell This study analyzed the effect of inotuzumab ozogamicin (InO; Besponsa) treatment on time to subsequent salvage therapy (TST) in patients with relapsed or refractory acute lymphoblastic leukemia (R/R ALL). The data showed that TST was longer with InO compared to standard of care (SoC) treatment. Some background Salvage...
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In a nutshell This study evaluated the effectiveness and safety of the combination of trifluridine-tipiracil (Lonsurf) and bevacizumab (Avastin) in patients with unresponsive (refractory) metastatic colorectal cancer (mCRC) in a real-world setting. The main finding was that trifluridine–tipiracil plus bevacizumab was safe and effective in...
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In a nutshell This study compared the long-term outcomes of percutaneous coronary intervention (PCI) using everolimus (Afinitor)-eluting stents (Xience) versus coronary artery bypass grafting (CABG) in patients with multivessel coronary artery disease (CAD). The data showed that both treatments were associated with a similar risk of heart attack, stroke,...
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In a nutshell This study evaluated the effects of acupuncture combined with metformin (Glucophage) versus metformin alone on pregnancy rate in women with polycystic ovary syndrome (PCOS). The data showed that acupuncture combined with metformin improved the pregnancy rate, ovulation rate, and insulin resistance compared with metformin treatment alone in...
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