In a nutshell This study evaluated the effectiveness and safety of indobufen (Ibustrin) plus clopidogrel (Plavix) versus aspirin plus clopidogrel in patients with negative cardiac troponin undergoing percutaneous coronary intervention (PCI) with drug-eluting stent (DES). The data showed that indobufen plus clopidogrel significantly reduced the risk of...
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Evaluating the effectiveness and safety of mirabegron and solifenacin combination in patients with double-J stent related overactive bladder symptoms.
In a nutshell This study evaluated the effectiveness and safety of mirabegron (Myrbetriq) and solifenacin (Vesicare) combination in patients with double-J stent-related overactive bladder (OAB) symptoms. The study found that mirabegron and solifenacin combination significantly improved urinary symptoms, OAB symptoms, and the quality of life with...
Read MoreCan new glucose-lowering medications influence stroke risk in patients with type 2 diabetes?
In a nutshell This review assessed the effects of new glucose-lowering drugs on stroke risk in patients with type 2 diabetes (T2D). The study showed that glucagon-like peptide-1 receptor (GLP-1) agonists are potentially beneficial for stroke risk in patients with T2D. Some background Patients with diabetes are at a higher risk of developing...
Read MoreComparing the long-term effectiveness and safety of trastuzumab deruxtecan versus trastuzumab emtansine in patients with HER2-positive metastatic breast cancer
In a nutshell The study compared the effectiveness and safety of trastuzumab deruxtecan (TD; Enhertu) with trastuzumab emtansine (TE; Kadcyla) in patients with HER2-positive (HER2+) metastatic breast cancer (BC). The study found that TD was more effective and well-tolerated compared to TE in these patients. Some background HER2+ BC...
Read MoreEvaluating the effectiveness of decitabine combined with allogeneic hematopoietic stem cell transplantation for the treatment of patients with recurrent and refractory acute myeloid leukemia.
In a nutshell This study evaluated the effectiveness of decitabine (Dacogen) combined with allogeneic hematopoietic stem cell transplantation (allo-HSCT) for the treatment of patients with recurrent and refractory (r/r) acute myeloid leukemia (AML). The data showed that decitabine combined with allo-HSCT reduced the risk of recurrence and improved...
Read MoreEvaluating the effectiveness of progestin-primed ovarian stimulation protocol for infertile patients with different ovarian reserve functions.
In a nutshell This study evaluated the effectiveness of progestin-primed ovarian stimulation (PPOS) protocol for infertile patients with different ovarian reserve functions. The data showed that PPOS is an effective ovarian stimulation protocol and is beneficial for these patients. Some background Many couples with infertility opt to use assisted...
Read MoreDoes transcranial direct current stimulation improve speech production in patients with speech impairment after stroke?
In a nutshell This study evaluated the effectiveness of transcranial direct current stimulation (tDCS) on speech intelligibility, and speech-related physiological and vocal functions in dysarthric (speech impairment) patients after stroke. The data showed that tDCS enhanced the effects of traditional speech therapy in these patients. Some...
Read MoreEvaluating the effectiveness and safety of pembrolizumab for the treatment of patients with relapsed or refractory classical Hodgkin lymphoma before stem cell transplantation.
In a nutshell This study evaluated the effectiveness and safety of pembrolizumab (Keytruda) for the treatment of patients with relapsed or refractory (r/r) classical Hodgkin lymphoma (cHL) before stem cell transplantation. The data showed that pembrolizumab was effective and safe with manageable side effects in these patients. Some background...
Read MoreEvaluating the effectiveness of chemotherapy for patients with resectable colorectal cancer liver metastases.
In a nutshell This study evaluated the effectiveness of chemotherapy before surgery for the treatment of patients with resectable colorectal cancer liver metastasis (CRLM). The data showed that the addition of chemotherapy before surgery significantly improved disease-free survival (survival without any signs or symptoms of cancer) but not the...
Read MoreEvaluating the effectiveness and safety of olaparib with or without cediranib in patients with metastatic castration-resistant prostate cancer.
In a nutshell This study evaluated the effectiveness and safety of olaparib (Lynparza) with or without cediranib (Recentin) in patients with metastatic castration-resistant prostate cancer (mCRPC). The data showed that cediranib combined with olaparib significantly improved survival without cancer worsening compared with olaparib alone in these patients....
Read MoreEvaluating the long-term outcomes of nivolumab plus ipilimumab versus chemotherapy as first-line treatment for advanced non-small cell lung cancer.
In a nutshell This evaluated the long-term outcomes of nivolumab (Opdivo) plus ipilimumab (Yervoy) versus chemotherapy as first-line treatment for advanced non-small cell lung cancer (NSCLC). The data showed that nivolumab plus ipilimumab increased the long-term overall survival versus chemotherapy in these patients. Some background NSCLC is the most...
Read MoreComparing the long-term effectiveness of accelerated partial breast irradiation using multicatheter brachytherapy with whole-breast irradiation in patients with early breast cancer
In a nutshell The study evaluated the long-term effectiveness of accelerated partial breast irradiation (ABPI) using multicatheter brachytherapy (BT) with whole-breast irradiation (WBI) in patients with early breast cancer (BC). The study found that ABPI using multicatheter BT was similarly effective with fewer serious side effects compared to...
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