In a nutshell This study investigated if reducing the doses (tapering) of biologic drugs maintains effectiveness in patients with rheumatoid arthritis (RA). They found that drug tapering maintained low disease activity (LDA) and remission while reducing side effects and costs. Some background Rheumatoid arthritis (RA) is a chronic...
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In a nutshell This study looked at activating oocytes (eggs) with calcium ions prior to intracytoplasmic sperm injection (ICSI). It found that this treatment improves fertilization rates for couples with male infertility, and may improve pregnancy rates. Some background ICSI is an infertility treatment used when there are few sperm available. It...
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In a nutshell This study investigated if slow release (SR) intrauterine insemination (IUI) improves pregnancy rates in women with infertility. They found that SR-IUI may improve pregnancy rates in women under 35 years of age. Some background Infertility affects many couples. Assisted reproductive techniques (ART) can be used to achieve a pregnancy....
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In a nutshell This study investigated the benefits of repeated cytoreductive surgery (CRS) and hyperthermic peritoneal chemotherapy (HIPEC) in patients with advanced colorectal cancer. Researchers suggested that repeated treatment improves the survival of patients with advanced colorectal cancer, without an increase in side effects. Some background...
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In a nutshell This study aimed to investigate kidney function in patients with chronic-phase (CP) chronic myeloid leukemia (CML) before and after tyrosine kinase inhibitor (TKI) treatment. This study concluded that long-term TKI treatment leads to kidney side effects in these patients that may be irreversible after stopping...
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In a nutshell This study examined older patients with Hodgkin lymphoma (HL) to understand how other serious health conditions affect their diagnosis and treatment. The authors found that patients with more serious illnesses were more likely to be diagnosed with advanced HL and had limited treatment options. Some background Treatment options for...
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In a nutshell This study compared two doses of dapagliflozin (Farxiga) to a placebo to determine how effective and safe they were long-term for patients with uncontrolled type 1 diabetes (T1D). The results showed that both doses were able to reduce blood glucose levels and body weight but increased the risk of ketoacidosis. Some background...
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In a nutshell This study compared the effectiveness and safety of bevacizumab biosimilar (BE1040V) to the reference drug (Avastin) in the treatment of patients with metastatic colorectal cancer (mCRC). Researchers suggested that the effectiveness and safety of the biosimilar were similar to the reference drug bevacizumab. Some...
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In a nutshell This study looked at exenatide (Byetta) for patients with type 2 diabetes (T2D) and kidney damage. It found that exenatide may reduce kidney damage compared to other diabetes treatments. Some background T2D is a disorder in which the body does not respond well to the hormone insulin. This causes high levels of glucose (sugar) in the...
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In a nutshell This analysis looked at the risk of miscarriage with increasing paternal age. It found that pregnancies by fathers over age 40 had a higher risk of miscarriage. Some background Miscarriages are unfortunately common, with over 10% of recognized pregnancies and an estimated 30% of all pregnancies ending in miscarriage. In 50 to 70% of...
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In a nutshell This study investigated if body mass index (BMI; a measurement of weight in relation to height) is associated with newborn outcomes (NOs) in women with endometrosis (EDM). They found that underweight women had higher rates of preterm birth (PTB). Some background Endometriosis (EDM) is a condition where uterine tissue...
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In a nutshell This study compared ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) and brentuximab vedotin (Adcedris; A) + AVD (doxorubicin, vinblastine, and dacarbazine) chemotherapy combinations to understand which is more effective long term for patients with advanced classical Hodgkin lymphoma (HL). The authors concluded...
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